Stephane Schurmans
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Explore the profile of Stephane Schurmans including associated specialties, affiliations and a list of published articles.
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58
Citations
1893
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Recent Articles
1.
Ando K, Kucukali F, Doeraene E, Nagaraj S, Antonelli E, Thazin Htut M, et al.
Acta Neuropathol
. 2024 Jun;
147(1):94.
PMID: 38833073
A recent large genome-wide association study has identified EGFR (encoding the epidermal growth factor EGFR) as a new genetic risk factor for late-onset AD. SHIP2, encoded by INPPL1, is taking...
2.
Fernandes S, Srivastava N, Pedicone C, Sudan R, Luke E, Dungan O, et al.
iScience
. 2023 Feb;
26(2):106071.
PMID: 36818285
Here we extend the understanding of how chemical inhibition of SHIP paralogs controls obesity. We compare different classes of SHIP inhibitors and find that selective inhibitors of SHIP1 or SHIP2...
3.
Moes B, Li H, Molina-Ortiz P, Radermecker C, Rosu A, Vande Catsyne C, et al.
Blood
. 2023 Jan;
141(14):1708-1717.
PMID: 36599086
The downstream signaling of the interleukin-7 (IL-7) receptor (IL-7R) plays important physiological and pathological roles, including the differentiation of lymphoid cells and proliferation of acute lymphoblastic leukemia cells. Gain-of-function mutations...
4.
Michael M, McCormick B, Anderson K, Karmakar U, Vermeren M, Schurmans S, et al.
Front Immunol
. 2021 May;
12:671756.
PMID: 33953730
Neutrophils, the most abundant circulating leukocytes in humans have key roles in host defense and in the inflammatory response. Agonist-activated phosphoinositide 3-kinases (PI3Ks) are important regulators of many facets of...
5.
Marongiu L, Mingozzi F, Cigni C, Marzi R, Gioia M, Garre M, et al.
Sci Signal
. 2021 Mar;
14(676).
PMID: 33785611
Innate immune responses to Gram-negative bacteria depend on the recognition of lipopolysaccharide (LPS) by a receptor complex that includes CD14 and TLR4. In dendritic cells (DCs), CD14 enhances the activation...
6.
Ukhanov K, Uytingco C, Green W, Zhang L, Schurmans S, Martens J
J Cell Sci
. 2021 Mar;
135(5).
PMID: 33771931
The lipid composition of the primary cilia membrane is emerging as a critical regulator of cilia formation, maintenance and function. Here, we show that conditional deletion of the phosphoinositide 5'-phosphatase...
7.
Schurmans S, Vande Catsyne C, Desmet C, Moes B
Adv Biol Regul
. 2020 Oct;
79:100760.
PMID: 33060052
INPP5K (Inositol Polyphosphate 5-Phosphatase K, or SKIP (for Skeletal muscle and Kidney enriched Inositol Phosphatase) is a member of the phosphoinositide 5-phosphatases family. Its protein structure is comprised of a...
8.
Constable S, Long A, Floyd K, Schurmans S, Caspary T
Development
. 2020 Jan;
147(3).
PMID: 31964774
Sonic hedgehog (Shh) signal transduction specifies ventral cell fates in the neural tube and is mediated by the Gli transcription factors that play both activator (GliA) and repressor (GliR) roles....
9.
Guo J, Otis J, Suciu S, Catalano C, Xing L, Constable S, et al.
Dev Cell
. 2019 Dec;
51(6):759-774.e5.
PMID: 31846650
Appropriate axonal growth and connectivity are essential for functional wiring of the brain. Joubert syndrome-related disorders (JSRD), a group of ciliopathies in which mutations disrupt primary cilia function, are characterized...
10.
Singh S, de Bruijn M, Velaso Gago da Graca C, Corneth O, Rip J, Stadhouders R, et al.
J Immunol
. 2019 Dec;
204(2):360-374.
PMID: 31836657
Balanced activity of kinases and phosphatases downstream of the BCR is essential for B cell differentiation and function and is disturbed in chronic lymphocytic leukemia (CLL). In this study, we...