Stephane Flibotte
Overview
Explore the profile of Stephane Flibotte including associated specialties, affiliations and a list of published articles.
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Articles
85
Citations
1966
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Recent Articles
31.
Au V, Li-Leger E, Raymant G, Flibotte S, Chen G, Martin K, et al.
G3 (Bethesda)
. 2018 Nov;
9(1):135-144.
PMID: 30420468
The Gene Knockout Consortium is tasked with obtaining null mutations in each of the more than 20,000 open reading frames (ORFs) of this organism. To date, approximately 15,000 ORFs have...
32.
Noblett N, Wu Z, Ding Z, Park S, Roenspies T, Flibotte S, et al.
J Cell Biol
. 2018 Nov;
218(1):125-133.
PMID: 30396999
Neuronal morphology and circuitry established during early development must often be maintained over the entirety of animal lifespans. Compared with neuronal development, the mechanisms that maintain mature neuronal structures and...
33.
Konrad A, Flibotte S, Taylor J, Waterston R, Moerman D, Bergthorsson U, et al.
Proc Natl Acad Sci U S A
. 2018 Jun;
115(28):7386-7391.
PMID: 29941601
Gene duplication and deletion are pivotal processes shaping the structural and functional repertoire of genomes, with implications for disease, adaptation, and evolution. We employed a mutation accumulation (MA) framework partnered...
34.
Wiesenfahrt T, Duanmu J, Snider F, Moerman D, Au V, Li-Leger E, et al.
G3 (Bethesda)
. 2018 Mar;
8(5):1425-1437.
PMID: 29593072
The ELT-2 GATA factor normally functions in differentiation of the endoderm, downstream of endoderm specification. We have previously shown that, if ELT-2 is expressed sufficiently early, it is also able...
35.
Lissemore J, Connors E, Liu Y, Qiao L, Yang B, Edgley M, et al.
G3 (Bethesda)
. 2018 Mar;
8(5):1535-1544.
PMID: 29507057
In a genetic screen to identify genes that promote GLP-1/Notch signaling in germline stem cells, we found a single mutation, , defining a gene called causes several defects in the...
36.
Kale A, Ji Z, Kiparaki M, Blanco J, Rimesso G, Flibotte S, et al.
Dev Cell
. 2018 Jan;
44(1):42-55.e4.
PMID: 29316439
Wild-type Drosophila cells can remove cells heterozygous for ribosomal protein mutations (known as "Minute" mutant cells) from genetic mosaics, a process termed cell competition. The ribosomal protein S12 was unusual...
37.
Page M, Skovso S, Cen H, Chiu A, Dionne D, Hutchinson D, et al.
FASEB J
. 2017 Nov;
32(3):1196-1206.
PMID: 29122848
Excess circulating insulin is associated with obesity in humans and in animal models. However, the physiologic causality of hyperinsulinemia in adult obesity has rightfully been questioned because of the absence...
38.
Templeman N, Flibotte S, Chik J, Sinha S, Lim G, Foster L, et al.
Cell Rep
. 2017 Jul;
20(2):451-463.
PMID: 28700945
The causal relationships between insulin levels, insulin resistance, and longevity are not fully elucidated. Genetic downregulation of insulin/insulin-like growth factor 1 (Igf1) signaling components can extend invertebrate and mammalian lifespan,...
39.
Comyn S, Flibotte S, Mayor T
Sci Rep
. 2017 Jun;
7(1):4183.
PMID: 28646136
Proteostasis promotes viability at both the cellular and organism levels by maintaining a functional proteome. This requires an intricate protein quality control (PQC) network that mediates protein folding by molecular...
40.
Acton E, Lee A, Zhao P, Flibotte S, Neira M, Sinha S, et al.
Open Biol
. 2017 Jun;
7(6).
PMID: 28592509
The Yeast Knockout (YKO) collection has provided a wealth of functional annotations from genome-wide screens. An unintended consequence is that 76% of gene annotations derive from one genotype. The nutritional...