Stefano Fedeli
Overview
Explore the profile of Stefano Fedeli including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
227
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Recent Articles
1.
Hirschbiegel C, Goswami R, Chakraborty S, Noonan C, Pham E, Nagaraj H, et al.
J Polym Sci (2020)
. 2024 Oct;
62(16):3787-3793.
PMID: 39444844
Synthetic polymer scaffolds can encapsulate transition metal catalysts (TMCs) to provide bioorthogonal nanocatalysts. These 'polyzymes' catalyze the generation of therapeutic agents without disrupting native biological processes. The design and modification...
2.
Liu L, Zhang X, Fedeli S, Cicek Y, Ndugire W, Rotello V
Materials (Basel)
. 2024 Apr;
17(7).
PMID: 38612022
Bio-orthogonal chemistry provides a powerful tool for drug delivery systems due to its ability to generate therapeutic agents in situ, minimizing off-target effects. Bio-orthogonal transition metal catalysts (TMCs) with stimuli-responsive...
3.
Huang R, Fedeli S, Hirschbiegel C, Zhang X, Rotello V
ACS Nanosci Au
. 2024 Feb;
4(1):62-68.
PMID: 38406311
Ligand dynamics plays a critical role in the chemical and biological properties of gold nanoparticles (AuNPs). In this study, ligands featuring hydrophobic alkanethiol interiors and hydrophilic shells were used to...
4.
Zhang X, Liu Y, Jiang M, Mas-Rosario J, Fedeli S, Cao-Milan R, et al.
Chem Sci
. 2024 Feb;
15(7):2486-2494.
PMID: 38362405
Macrophages are plastic cells of the immune system that can be broadly classified as having pro-inflammatory (M1-like) or anti-inflammatory (M2-like) phenotypes. M2-like macrophages are often associated with cancers and can...
5.
Nabawy A, Gupta A, Jiang M, Hirschbiegel C, Fedeli S, Chattopadhyay A, et al.
Nanoscale
. 2023 Aug;
15(33):13595-13602.
PMID: 37554065
Bioorthogonal catalysis mediated by transition metal catalysts (TMCs) provides controlled activation of prodrugs through chemical reactions that do not interfere with cellular bioprocesses. The direct use of 'naked' TMCs in...
6.
Jiang M, Gupta A, Zhang X, Chattopadhyay A, Fedeli S, Huang R, et al.
Anal Sens
. 2023 May;
3(3).
PMID: 37250385
The rapid detection of proteins is very important in the early diagnosis of diseases. Gold nanoparticles (AuNPs) can be engineered to bind biomolecules efficiently and differentially. Cross-reactive sensor arrays have...
7.
Schain F, Boissin C, Laczik T, Fedeli S, Remberger M, Blennow O, et al.
Transfus Apher Sci
. 2023 Mar;
62(3):103705.
PMID: 36967367
Background: Extracorporeal photopheresis (ECP) is frequently used to treat moderate-severe chronic graft versus host disease (cGVHD), however limited data exists describing ECP treatment effects on healthcare and societal costs. We...
8.
Zhang X, Liu Y, Doungchawee J, Castellanos-Garcia L, Sikora K, Jeon T, et al.
J Control Release
. 2023 Mar;
357:31-39.
PMID: 36948419
Bioorthogonal catalysis via transition metal catalysts (TMCs) enables the generation of therapeutics locally through chemical reactions not accessible by biological systems. This localization can enhance the efficacy of anticancer treatment...
9.
Fedeli S, Huang R, Oz Y, Zhang X, Gupta A, Gopalakrishnan S, et al.
ACS Appl Mater Interfaces
. 2023 Mar;
15(12):15260-15268.
PMID: 36920076
Bioorthogonal activation of pro-dyes and prodrugs using transition-metal catalysts (TMCs) provides a promising strategy for imaging and therapeutic applications. TMCs can be loaded into polymeric nanoparticles through hydrophobic encapsulation to...
10.
Hirschbiegel C, Zhang X, Huang R, Cicek Y, Fedeli S, Rotello V
Adv Drug Deliv Rev
. 2023 Feb;
195:114730.
PMID: 36791809
Bioorthogonal transition metal catalysts (TMCs) transform therapeutically inactive molecules (pro-drugs) into active drug compounds. Inorganic nanoscaffolds protect and solubilize catalysts while offering a flexible design space for decoration with targeting...