Stefan Verhoog
Overview
Explore the profile of Stefan Verhoog including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
19
Citations
429
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Webb E, Cheng K, Winton W, Klein B, Bowden G, Horikawa M, et al.
J Am Chem Soc
. 2024 Apr;
146(15):10581-10590.
PMID: 38580459
Positron emission tomography is a widely used imaging platform for studying physiological processes. Despite the proliferation of modern synthetic methodologies for radiolabeling, the optimization of these reactions still primarily relies...
2.
Pipal R, Stout K, Musacchio P, Ren S, Graham T, Verhoog S, et al.
Nature
. 2020 Nov;
589(7843):542-547.
PMID: 33238289
Positron emission tomography (PET) radioligands (radioactively labelled tracer compounds) are extremely useful for in vivo characterization of central nervous system drug candidates, neurodegenerative diseases and numerous oncology targets. Both tritium...
3.
Guibbal F, Isenegger P, Wilson T, Pacelli A, Mahaut D, Sap J, et al.
Nat Protoc
. 2020 Mar;
15(4):1525-1541.
PMID: 32111986
Positron emission tomography (PET) is a diagnostic nuclear imaging modality that relies on automated protocols to prepare agents labeled with a positron-emitting radionuclide (e.g., F). In recent years, new reactions...
4.
Kee C, Tack O, Guibbal F, Wilson T, Isenegger P, Imiolek M, et al.
J Am Chem Soc
. 2020 Jan;
142(3):1180-1185.
PMID: 31913613
F labeling strategies for unmodified peptides with [F]fluoride require F-labeled prosthetics for bioconjugation more often with cysteine thiols or lysine amines. Here we explore selective radical chemistry to target aromatic...
5.
Verhoog S, Brooks A, Winton W, Viglianti B, Sanford M, Scott P
Chem Commun (Camb)
. 2019 May;
55(45):6361-6364.
PMID: 31062010
A simple technique for the preparation of [18F]HF has been developed and applied to the generation of an [18F]FeF species for opening sterically hindered epoxides. This method has been successfully...
6.
Wu J, Zhao Q, Wilson T, Verhoog S, Lu L, Gouverneur V, et al.
Angew Chem Int Ed Engl
. 2018 Dec;
58(8):2413-2417.
PMID: 30575245
A highly reactive electrophilic bromodifluoromethylthiolating reagent, α-cumyl bromodifluoro-methanesulfenate 1, was prepared to allow for direct bromodifluoromethylthiolation of aryl boron reagents. This coupling reaction takes place under copper catalysis, and affords...
7.
Wilson T, Xavier M, Knight J, Verhoog S, Torres J, Mosley M, et al.
J Nucl Med
. 2018 Nov;
60(4):504-510.
PMID: 30389822
Poly(ADP-ribose) polymerase (PARP) inhibitors are increasingly being studied as cancer drugs, as single agents, or as a part of combination therapies. Imaging of PARP using a radiolabeled inhibitor has been...
8.
Verhoog S, Kee C, Wang Y, Khotavivattana T, Wilson T, Kersemans V, et al.
J Am Chem Soc
. 2018 Jan;
140(5):1572-1575.
PMID: 29301394
The F-labeling of 5-(trifluoromethyl)-dibenzothiophenium trifluoromethanesulfonate, commonly referred to as the Umemoto reagent, has been accomplished applying a halogen exchange F-fluorination with F-fluoride, followed by oxidative cyclization with Oxone and trifluoromethanesulfonic...
9.
Taylor N, Emer E, Preshlock S, Schedler M, Tredwell M, Verhoog S, et al.
J Am Chem Soc
. 2017 May;
139(24):8267-8276.
PMID: 28548849
Molecules labeled with fluorine-18 (F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of F onto...
10.
Khotavivattana T, Calderwood S, Verhoog S, Pfeifer L, Preshlock S, Vasdev N, et al.
Org Lett
. 2017 Jan;
19(3):568-571.
PMID: 28085289
In this work, we describe the F-labeling of α,α-difluoro-α-(aryloxy)acetic acid derivatives and demonstrate that these building blocks are amenable to post-F-fluorination functionalization. Protodecarboxylation offers a new entry to F-difluoromethoxyarene, and...