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Stefan M Woerner

Explore the profile of Stefan M Woerner including associated specialties, affiliations and a list of published articles. Areas
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Articles 14
Citations 491
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Recent Articles
1.
Michalak M, Katzenmaier E, Roeckel N, Woerner S, Fuchs V, Warnken U, et al.
Int J Mol Sci . 2020 Jul; 21(15). PMID: 32718059
DNA mismatch repair-deficient colorectal cancers (CRCs) accumulate numerous frameshift mutations at repetitive sequences recognized as microsatellite instability (MSI). When coding mononucleotide repeats (cMNRs) are affected, tumors accumulate frameshift mutations and...
2.
Moghaddam A, Graeser V, Westhauser F, Dapunt U, Kamradt T, Woerner S, et al.
Ther Clin Risk Manag . 2016 Sep; 12:1387-93. PMID: 27660456
Introduction: Osteitis is one of the most serious complications in orthopedic surgery. Expert Tibia Nail (ETN) PROtect™ coated with a biodegradable layer of gentamicin-laden polymer was developed for prophylaxis of...
3.
Woerner S, Tosti E, Yuan Y, Kloor M, Bork P, Edelmann W, et al.
Mol Carcinog . 2014 Sep; 54(11):1376-86. PMID: 25213383
Different DNA mismatch repair (MMR)-deficient mouse strains have been developed as models for the inherited cancer predisposing Lynch syndrome. It is completely unresolved, whether coding mononucleotide repeat (cMNR) gene mutations...
4.
Mazzolini R, Rodrigues P, Bazzocco S, Dopeso H, Ferreira A, Mateo-Lozano S, et al.
Int J Cancer . 2012 Sep; 132(8):1790-9. PMID: 23002058
Brush border Myosin Ia (MYO1A) has been shown to be frequently mutated in colorectal tumors with microsatellite instability (MSI) and to have tumor suppressor activity in intestinal tumors. Here, we...
5.
Woerner S, Yuan Y, Benner A, Korff S, von Knebel Doeberitz M, Bork P
Nucleic Acids Res . 2009 Oct; 38(Database issue):D682-9. PMID: 19820113
About 15% of human colorectal cancers and, at varying degrees, other tumor entities as well as nearly all tumors related to Lynch syndrome are hallmarked by microsatellite instability (MSI) as...
6.
Roeckel N, Woerner S, Kloor M, Yuan Y, Patsos G, Gromes R, et al.
Cancer Res . 2009 Jan; 69(1):292-9. PMID: 19118014
Glycosyl epitopes have been identified as tumor-specific markers in colorectal tumors and various lines of evidence indicate the significance of altered synthesis, transport, and secretion of glycoproteins in tumorigenesis. However,...
7.
Korff S, Woerner S, Yuan Y, Bork P, von Knebel Doeberitz M, Gebert J
BMC Cancer . 2008 Nov; 8:329. PMID: 19000305
Background: Protein tyrosine phosphatases (PTPs) like their antagonizing protein tyrosine kinases are key regulators of signal transduction thereby assuring normal control of cellular growth and differentiation. Increasing evidence suggests that...
8.
Woerner S, Kloor M, Schwitalle Y, Youmans H, von Knebel Doeberitz M, Gebert J, et al.
Genes Chromosomes Cancer . 2007 Aug; 46(12):1080-9. PMID: 17726700
Mismatch repair (MMR) deficiency is a major mechanism of colorectal tumorigenesis that is observed in 10-15% of sporadic colorectal cancers and those associated with the hereditary nonpolyposis colorectal cancer (HNPCC)...
9.
Woerner S, Kloor M, von Knebel Doeberitz M, Gebert J
Cancer Biomark . 2006 Dec; 2(1-2):69-86. PMID: 17192061
Microsatellites are highly abundant short repetitive sequences found in the genomes across different species. They have gained increasing interest in recent years because length alterations in several coding as well...
10.
Alazzouzi H, Davalos V, Kokko A, Domingo E, Woerner S, Wilson A, et al.
Cancer Res . 2005 Nov; 65(22):10170-3. PMID: 16288001
The receptor tyrosine kinase EPHB2 has recently been shown to be a direct transcriptional target of TCF/beta-catenin. Premalignant lesions of the colon express high levels of EPHB2 but the expression...