Stefan Henrich
Overview
Explore the profile of Stefan Henrich including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
527
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Recent Articles
1.
Costantino L, Ferrari S, Santucci M, Salo-Ahen O, Carosati E, Franchini S, et al.
Elife
. 2022 Dec;
11.
PMID: 36475542
Drugs that target human thymidylate synthase (hTS), a dimeric enzyme, are widely used in anticancer therapy. However, treatment with classical substrate-site-directed TS inhibitors induces over-expression of this protein and development...
2.
Borsari C, Luciani R, Pozzi C, Poehner I, Henrich S, Trande M, et al.
J Med Chem
. 2016 Jul;
59(16):7598-616.
PMID: 27411733
Flavonoids represent a potential source of new antitrypanosomatidic leads. Starting from a library of natural products, we combined target-based screening on pteridine reductase 1 with phenotypic screening on Trypanosoma brucei...
3.
Fuller J, Martinez M, Henrich S, Stank A, Richter S, Wade R
Bioinformatics
. 2014 Dec;
31(7):1147-9.
PMID: 25433696
Unlabelled: LigDig is a web server designed to answer questions that previously required several independent queries to diverse data sources. It also performs basic manipulations and analyses of the structures...
4.
Wade R, Henrich S, Wang T
Drug Discov Today Technol
. 2014 Jul;
1(3):241-6.
PMID: 24981491
The three-dimensional structures of proteins are being solved apace, yet this information is often underused in quantitative structure-activity relationship (QSAR) studies. Here, we describe and compare methods for exploiting protein...
5.
Organism-adapted specificity of the allosteric regulation of pyruvate kinase in lactic acid bacteria
Veith N, Feldman-Salit A, Cojocaru V, Henrich S, Kummer U, Wade R
PLoS Comput Biol
. 2013 Aug;
9(7):e1003159.
PMID: 23946717
Pyruvate kinase (PYK) is a critical allosterically regulated enzyme that links glycolysis, the primary energy metabolism, to cellular metabolism. Lactic acid bacteria rely almost exclusively on glycolysis for their energy...
6.
Kokh D, Richter S, Henrich S, Czodrowski P, Rippmann F, Wade R
J Chem Inf Model
. 2013 Apr;
53(5):1235-52.
PMID: 23621586
We present TRAPP (TRAnsient Pockets in Proteins), a new automated software platform for tracking, analysis, and visualization of binding pocket variations along a protein motion trajectory or within an ensemble...
7.
Cardinale D, Guaitoli G, Tondi D, Luciani R, Henrich S, Salo-Ahen O, et al.
Proc Natl Acad Sci U S A
. 2011 Jul;
108(34):E542-9.
PMID: 21795601
Human thymidylate synthase is a homodimeric enzyme that plays a key role in DNA synthesis and is a target for several clinically important anticancer drugs that bind to its active...
8.
Ferrari S, Morandi F, Motiejunas D, Nerini E, Henrich S, Luciani R, et al.
J Med Chem
. 2010 Dec;
54(1):211-21.
PMID: 21126022
Folate analogue inhibitors of Leishmania major pteridine reductase (PTR1) are potential antiparasitic drug candidates for combined therapy with dihydrofolate reductase (DHFR) inhibitors. To identify new molecules with specificity for PTR1,...
9.
Garg D, Henrich S, Salo-Ahen O, Myllykallio H, Costi M, Wade R
J Med Chem
. 2010 Jun;
53(18):6539-49.
PMID: 20527892
No abstract available.
10.
Henrich S, Feierberg I, Wang T, Blomberg N, Wade R
Proteins
. 2009 Sep;
78(1):135-53.
PMID: 19768680
A major challenge in drug design is to obtain compounds that bind selectively to their target receptors and do not cause side-effects by binding to other similar receptors. Here, we...