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Stefan Brase

Explore the profile of Stefan Brase including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 439
Citations 3284
Followers 0
Related Specialties
Chemistry
Biochemistry
Biology
Top 10 Co-Authors
Martin Nieger
Nicole Jung
Ute Schepers
Ashraf A Aly
Bahaa G M Youssif
Christof Woll
Zahid Hassan
Olaf Fuhr
Alaa A Hassan
Sylvain Grosjean
Published In
Chemistry
Molecules
Angew Chem Int Ed Engl
Chem Commun (Camb)
Org Biomol Chem
Affiliations
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Recent Articles
1.
Infrared spectrum analysis of organic molecules with neural networks using standard reference data sets in combination with real-world data
Punjabi D, Huang Y, Holzhauer L, Tremouilhac P, Friederich P, Jung N, et al.
J Cheminform . 2025 Feb; 17(1):24. PMID: 40011923
In this study, we propose a neural network- based approach to analyze IR spectra and detect the presence of functional groups. Our neural network architecture is based on the concept...
2.
Design, Synthesis, and Antiproliferative Activity of Novel Indole/1,2,4-Triazole Hybrids as Tubulin Polymerization Inhibitors
Mahmoud E, Abdelhamid D, Mohammed A, Almarhoon Z, Brase S, Youssif B, et al.
Pharmaceuticals (Basel) . 2025 Feb; 18(2). PMID: 40006087
New indole/1,2,4-triazole hybrids were synthesized and tested for antiproliferative activity against the NCI 60 cell line as tubulin polymerization inhibitors. All final compounds, - and - were evaluated at a...
3.
Enhancing FAIRdata by providing digital workflows from data generation to the publication of data: an open source approach described for cyclic voltammetry
Herrmann D, Hodapp P, Starman M, Huang P, Lin C, Le L, et al.
Chem Sci . 2025 Feb; 16(10):4430-4441. PMID: 39916882
Analytical data in chemistry and other disciplines is usually generated in different formats and lacks common data and metadata standards that are necessary for a FAIR handling of research data....
4.
Design, synthesis, and apoptotic antiproliferative action of new benzimidazole/1,2,3-triazole hybrids as EGFR inhibitors
Ahmed A, Mohammed A, Almarhoon Z, Brase S, Youssif B
Front Chem . 2025 Feb; 12:1541846. PMID: 39896136
Introduction: This work outlines the design, synthesis, and biological evaluation of a new series of benzimidazole/1,2,3-triazole hybrids as apoptotic antiproliferative agents that inhibit the EGFR pathway. Methods: The research assesses...
5.
From Infection to Tumor: Exploring the Therapeutic Potential of Ciprofloxacin Derivatives as Anticancer Agents
Hassan H, Hassan R, Elmagzoub R, Al-Emam A, Kossenas K, Abdel-Samea A, et al.
Pharmaceuticals (Basel) . 2025 Jan; 18(1). PMID: 39861135
Ciprofloxacin, a widely used second-generation fluoroquinolone for treating bacterial infections, has recently shown notable anticancer properties. This review explores progress in developing ciprofloxacin derivatives with anticancer properties, emphasizing key structural...
6.
Design, Synthesis, Anticancer Screening, and Mechanistic Study of Spiro-N-(4-sulfamoyl-phenyl)-1,3,4-thiadiazole-2-carboxamide Derivatives
El-Saghier A, Hashem H, Maher S, Enaili S, Alkhammash A, Brase S, et al.
Int J Mol Sci . 2025 Jan; 26(2). PMID: 39859577
The present study aims to create spiro-N-(4-sulfamoyl-phenyl)-1,3,4-thiadiazole-2-carboxamide derivatives with anticancer activities. The in vitro anticancer evaluation showed that only the novel spiro-acenaphthylene tethered-[1,3,4]-thiadiazole (compound ) exhibited significant anticancer efficacy as...
7.
Linking Research Data with Physically Preserved Research Materials in Chemistry
Lin C, Huang P, Grassle S, Grathwol C, Tremouilhac P, Vanderheiden S, et al.
Sci Data . 2025 Jan; 12(1):130. PMID: 39843501
Results of scientific work in chemistry can usually be obtained in the form of materials and data. A big step towards transparency and reproducibility of the scientific work can be...
8.
Identification of novel triazolylquinoxaline-based metal complexes supported by experimental and virtual screenings
Holzhauer L, Shekhovtsev V, Bruschi C, Gunther M, Fuhr O, Hodapp P, et al.
Dalton Trans . 2025 Jan; 54(8):3287-3295. PMID: 39831404
The formation of novel complexes from so far non-investigated ligands and different metal centers is important for the development of new functional materials such as (photo)catalysts or biologically active compounds....
9.
Fabrication and characterization of lactoperoxidase coated the modified graphene oxide-based nanocomposite for medical applications
Nayl A, El-Fakharany E, Abd-Elhamid A, Arafa W, Alanazi A, Ahmed I, et al.
Int J Biol Macromol . 2024 Dec; 288():138597. PMID: 39667452
This study aims to synthesize an innovative (GO-PAA-Cu-LP) nanocomposite through multi-steps for medical applications. First, graphene oxide (GO) was radically anchored with polyacrylic acid (PAA), subsequently, activation through substituting the...
10.
Design, synthesis, and antiproliferative activity of new 1,2,3-triazole/quinazoline-4-one hybrids as dual EGFR/BRAF inhibitors
Mohamed A, Abou-Ghadir O, Mostafa Y, Almarhoon Z, Brase S, Youssif B
RSC Adv . 2024 Dec; 14(52):38403-38415. PMID: 39640522
A novel series of 1,2,3-triazole/quinazoline-4-one hybrids (8a-t) were designed and synthesized as dual-targeted antiproliferative agents. Compounds 8a-t were evaluated for their antiproliferative efficacy against a panel of four cancer cell...