Stanley N Cohen
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Explore the profile of Stanley N Cohen including associated specialties, affiliations and a list of published articles.
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100
Citations
3936
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Recent Articles
1.
Deng N, Wu Y, Feng Y, Hsieh W, Song J, Lin Y, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(32):e2204779119.
PMID: 35914128
Earlier work has shown that siRNA-mediated reduction of the SUPT4H or SUPT5H proteins, which interact to form the DSIF complex and facilitate transcript elongation by RNA polymerase II (RNAPII), can...
2.
Deng N, Zhang Y, Ma Z, Lin R, Cheng T, Tang H, et al.
NAR Genom Bioinform
. 2022 Aug;
4(3):lqac054.
PMID: 35910045
The DSIF complex comprising the Supt4h and Supt5h transcription elongation proteins clamps RNA polymerase II (RNAPII) onto DNA templates, facilitating polymerase processivity. Lowering DSIF components can differentially decrease expression of...
3.
Moore C, Go H, Shin E, Ha H, Song S, Ha N, et al.
Genes Dev
. 2021 Jan;
35(3-4):286-299.
PMID: 33446571
RNase E is an essential, multifunctional ribonuclease encoded in by the gene. Structural analysis indicates that the ribonucleolytic activity of this enzyme is conferred by -encoded polypeptide chains that (1)...
4.
Wu K, Koo J, Jiang X, Chen R, Cohen S, Nathan C
PLoS One
. 2018 Oct;
13(10):e0205424.
PMID: 30289942
[This corrects the article DOI: 10.1371/journal.pone.0030512.].
5.
Leonardi W, Zilbermintz L, Cheng L, Zozaya J, Tran S, Elliott J, et al.
Sci Rep
. 2016 Oct;
6:34475.
PMID: 27686742
Diverse pathogenic agents often utilize overlapping host networks, and hub proteins within these networks represent attractive targets for broad-spectrum drugs. Using bacterial toxins, we describe a new approach for discovering...
6.
Kramer N, Carlomagno Y, Zhang Y, Almeida S, Cook C, Gendron T, et al.
Science
. 2016 Aug;
353(6300):708-12.
PMID: 27516603
An expanded hexanucleotide repeat in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal dementia (c9FTD/ALS). Therapeutics are being developed to target RNAs containing the expanded repeat sequence (GGGGCC); however, this approach...
7.
Tamura M, Honda N, Fujimoto H, Cohen S, Kato A
Arch Microbiol
. 2016 Feb;
198(5):409-21.
PMID: 26883538
Escherichia coli cells require RNase E, encoded by the essential gene rne, to propagate. The growth properties on different carbon sources of E. coli cells undergoing suppression of RNase E...
8.
Yan L, Chen Y, Li W, Huang X, Badie H, Jian F, et al.
Sci Rep
. 2016 Jan;
6:18668.
PMID: 26733416
Alzheimer's disease (AD) is the most common form of dementia in the elderly. It is generally believed that β-amyloidogenesis, tau-hyperphosphorylation, and synaptic loss underlie cognitive decline in AD. Rps23rg1, a...
9.
Zilbermintz L, Leonardi W, Jeong S, Sjodt M, McComb R, Ho C, et al.
Sci Rep
. 2015 Aug;
5:13476.
PMID: 26310922
A longstanding and still-increasing threat to the effective treatment of infectious diseases is resistance to antimicrobial countermeasures. Potentially, the targeting of host proteins and pathways essential for the detrimental effects...
10.