Stanley J Watowich
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Explore the profile of Stanley J Watowich including associated specialties, affiliations and a list of published articles.
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41
Citations
790
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Recent Articles
1.
Babula J, Bui D, Stevenson H, Watowich S, Neelakantan H
Diabetes Obes Metab
. 2024 Aug;
26(11):5272-5282.
PMID: 39161060
Aim: To assess the effects of a small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor, 5A1MQ, on body composition, metabolic variables, fatty liver pathologies, and circulating biomarkers in diet-induced obese (DIO) mice, and...
2.
Chambers T, Dimet-Wiley A, Keeble A, Haghani A, Lo W, Kang G, et al.
J Physiol
. 2024 Jul;
603(1):211-237.
PMID: 39058663
Exercise is a potent stimulus for combatting skeletal muscle ageing. To study the effects of exercise on muscle in a preclinical setting, we developed a combined endurance-resistance training stimulus for...
3.
Dimet-Wiley A, Latham C, Brightwell C, Neelakantan H, Keeble A, Thomas N, et al.
Sci Rep
. 2024 Jul;
14(1):15554.
PMID: 38969654
Human hallmarks of sarcopenia include muscle weakness and a blunted response to exercise. Nicotinamide N-methyltransferase inhibitors (NNMTis) increase strength and promote the regenerative capacity of aged muscle, thus offering a...
4.
Jones 3rd R, Dimet-Wiley A, Haghani A, Morena da Silva F, Brightwell C, Lim S, et al.
J Physiol
. 2022 Dec;
601(4):763-782.
PMID: 36533424
Exercise promotes functional improvements in aged tissues, but the extent to which it simulates partial molecular reprogramming is unknown. Using transcriptome profiling from (1) a skeletal muscle-specific in vivo Oct3/4,...
5.
Dungan C, Brightwell C, Wen Y, Zdunek C, Latham C, Thomas N, et al.
Function (Oxf)
. 2022 Jul;
3(4):zqac027.
PMID: 35774589
Murine exercise models can provide information on factors that influence muscle adaptability with aging, but few translatable solutions exist. Progressive weighted wheel running (PoWeR) is a simple, voluntary, low-cost, high-volume...
6.
Dimet-Wiley A, Golovko G, Watowich S
JMIR Aging
. 2022 Mar;
5(1):e32683.
PMID: 35293865
Background: Hip fracture in older adults is tied to increased mortality risk. Deconvolution of the mortality risk specific to hip fracture from that of various other fracture types has not...
7.
Murach K, Dimet-Wiley A, Wen Y, Brightwell C, Latham C, Dungan C, et al.
Aging Cell
. 2021 Dec;
21(1):e13527.
PMID: 34932867
There are functional benefits to exercise in muscle, even when performed late in life, but the contributions of epigenetic factors to late-life exercise adaptation are poorly defined. Using reduced representation...
8.
Sampson C, Dimet A, Neelakantan H, Ogunseye K, Stevenson H, Hommel J, et al.
Sci Rep
. 2021 Mar;
11(1):5637.
PMID: 33707534
Obesity is a large and growing global health problem with few effective therapies. The present study investigated metabolic and physiological benefits of nicotinamide N-methyltransferase inhibitor (NNMTi) treatment combined with a...
9.
Neelakantan H, Brightwell C, Graber T, Maroto R, Wang H, McHardy S, et al.
Biochem Pharmacol
. 2019 Feb;
163:481-492.
PMID: 30753815
Aging is accompanied by progressive declines in skeletal muscle mass and strength and impaired regenerative capacity, predisposing older adults to debilitating age-related muscle deteriorations and severe morbidity. Muscle stem cells...
10.
Neelakantan H, Vance V, Wetzel M, Wang H, McHardy S, Finnerty C, et al.
Biochem Pharmacol
. 2017 Nov;
147:141-152.
PMID: 29155147
There is a critical need for new mechanism-of-action drugs that reduce the burden of obesity and associated chronic metabolic comorbidities. A potentially novel target to treat obesity and type 2...