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Srividya Vasu

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Articles 36
Citations 399
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Recent Articles
1.
Mattke J, Darden C, Vasu S, Lawrence M, Kirkland J, Kane R, et al.
Cells . 2024 Mar; 13(5. PMID: 38474380
Islet transplantation is a therapeutic option to replace β-cell mass lost during type 1 or type 3c diabetes. Innate immune responses, particularly the instant blood-mediated inflammatory reaction and activation of...
2.
Vasu S, Saracino G, Darden C, Kumano K, Liu Y, Lawrence M, et al.
Clin Transl Med . 2023 Oct; 13(10):e1434. PMID: 37846205
Background: Specific microRNAs (miRNAs) were elevated in chronic pancreatitis (CP) patients during islet infusion after total pancreatectomy (TPIAT). We aimed to identify circulating miRNA signatures of pancreatic damage, predict miRNA-mRNA...
3.
Liu Y, Vasu S, Kumano K, Sorelle J, Lawrence M, Naziruddin B
J Gastrointest Surg . 2022 May; 26(8):1766-1768. PMID: 35641811
No abstract available.
4.
Darden C, Vasu S, Mattke J, Liu Y, Rhodes C, Naziruddin B, et al.
iScience . 2022 Apr; 25(4):104125. PMID: 35402865
Pancreatic islets respond to metabolic and inflammatory stress by producing hormones and other factors that induce adaptive cellular and systemic responses. Here we show that intracellular Ca ([Ca]) and ROS...
5.
Mattke J, Vasu S, Darden C, Kumano K, Lawrence M, Naziruddin B
Front Endocrinol (Lausanne) . 2021 Aug; 12:681600. PMID: 34447351
Exosomes are known for their ability to transport nucleic acid, lipid, and protein molecules, which allows for communication between cells and tissues. The cargo of the exosomes can have a...
6.
Kumano K, Kanak M, Saravanan P, Blanck J, Liu Y, Vasu S, et al.
Sci Rep . 2021 May; 11(1):10661. PMID: 34021233
The immunosuppressive regimen for clinical allogeneic islet transplantation uses beta cell-toxic compounds such as tacrolimus that cause islet graft loss. Previously we reported that the plant-derived steroidal lactone Withaferin A...
7.
Vasu S, Yang J, Hodges J, Abu-El-Haija M, Adams D, Balamurugan A, et al.
Cell Transplant . 2021 Apr; 30:963689721999330. PMID: 33902338
Circulating microRNAs (miRNAs) can be biomarkers for diagnosis and progression of several pathophysiological conditions. In a cohort undergoing total pancreatectomy with islet autotransplantation (TPIAT) from the multicenter Prospective Observational Study...
8.
Yoshimatsu G, Kanak M, Vasu S, Kumano K, Lawrence M, Onaca N, et al.
Cell Transplant . 2020 Sep; 29:963689720949242. PMID: 32878466
Total pancreatectomy with islet autotransplantation (TPIAT) is a promising treatment for refractory chronic pancreatitis (CP). Pathological features of CP include progressive fibrosis in pancreas parenchyma, atrophy, and/or ductal occlusion. Complete...
9.
Kumano K, Vasu S, Liu Y, Lo S, Mulgaonkar A, Pennington J, et al.
Transplantation . 2020 Jun; 104(11):2307-2316. PMID: 32541557
Background: Although the liver is the primary site for clinical islet transplantation, it poses several restrictions, especially limited tissue volume due to portal vein pressure. We evaluated the preperitoneal space...
10.
Kumano K, Takita M, Vasu S, Darden C, Lawrence M, Beecherl E, et al.
J Hepatobiliary Pancreat Sci . 2020 Jan; 27(4):211-218. PMID: 31944603
Background: The combined use of interleukin-1β and tumor necrosis factor-α blockers in the peritransplant period has improved outcomes of total pancreatectomy with islet autotransplantation (TPIAT). However, these drugs may suppress...