Srishti U Sahu
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Explore the profile of Srishti U Sahu including associated specialties, affiliations and a list of published articles.
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6
Citations
64
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Recent Articles
1.
Sahu S, Castro M, Muldoon J, Asija K, Wyman S, Krishnappa N, et al.
Nat Protoc
. 2025 Mar;
PMID: 40032999
Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) is a new approach for ex vivo genome editing of primary human cells. PERC uses a single amphiphilic peptide reagent to mediate intracellular...
2.
George C, Sahu S, de Onate L, Souza B, Wilson R
CRISPR J
. 2024 Sep;
7(5):231-248.
PMID: 39324895
Hematopoietic stem cells (HSCs) provide the body with a continuous supply of healthy, functional blood cells. In patients with hematopoietic malignancies, immunodeficiencies, lysosomal storage disorders, and hemoglobinopathies, therapeutic genome editing...
3.
Foss D, Muldoon J, Nguyen D, Carr D, Sahu S, Hunsinger J, et al.
Nat Biomed Eng
. 2023 May;
7(5):647-660.
PMID: 37147433
CRISPR-mediated genome editing of primary human lymphocytes is typically carried out via electroporation, which can be cytotoxic, cumbersome and costly. Here we show that the yields of edited primary human...
4.
Bowers M, Cacheaux L, Sahu S, Schmidt M, Sennello J, Leaderbrand K, et al.
J Neurochem
. 2019 Aug;
152(5):523-541.
PMID: 31376158
N-methyl-d-aspartate receptors (NMDARs) mediate both physiological and pathophysiological processes, although selective ligands lack broad clinical utility. NMDARs are composed of multiple subunits, but N-methyl-d-aspartate receptor subunit 2 (GluN2) is predominately...
5.
6.
Sahu S, Visetsouk M, Garde R, Hennes L, Kwas C, Gutzman J
Mol Biol Cell
. 2017 Feb;
28(7):875-882.
PMID: 28148652
One of the first morphogenetic events in the vertebrate brain is the formation of the highly conserved midbrain-hindbrain boundary (MHB). Specific cell shape changes occur at the point of deepest...
7.
Gutzman J, Sahu S, Kwas C
Dev Biol
. 2014 Dec;
397(1):103-15.
PMID: 25446029
During brain morphogenesis, the neuroepithelium must fold in specific regions to delineate functional units, and give rise to conserved embryonic brain shape. Individual cell shape changes are the basis for...