Joseph J Muldoon
Overview
Explore the profile of Joseph J Muldoon including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
181
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Recent Articles
1.
Sahu S, Castro M, Muldoon J, Asija K, Wyman S, Krishnappa N, et al.
Nat Protoc
. 2025 Mar;
PMID: 40032999
Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) is a new approach for ex vivo genome editing of primary human cells. PERC uses a single amphiphilic peptide reagent to mediate intracellular...
2.
Chang C, Vykunta V, Lee J, Li K, Kochendoerfer C, Muldoon J, et al.
Nat Biotechnol
. 2025 Feb;
PMID: 39910194
Engineering T cell specificity and function at multiple loci can generate more effective cellular therapies, but current manufacturing methods produce heterogenous mixtures of partially engineered cells. Here we develop a...
3.
Nyberg W, Wang C, Ark J, Liu C, Clouden S, Qualls A, et al.
Immunity
. 2025 Feb;
58(2):499-512.e7.
PMID: 39909036
Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells in vivo using an evolved adeno-associated...
4.
Jung J, Dreyer K, Dray K, Muldoon J, George J, Shirman S, et al.
ACS Synth Biol
. 2024 Dec;
14(1):129-147.
PMID: 39670656
Recent years have seen intense interest in the development of point-of-care nucleic acid diagnostic technologies to address the scaling limitations of laboratory-based approaches. Chief among these are combinations of isothermal...
5.
Sahu S, Castro M, Muldoon J, Asija K, Wyman S, Krishnappa N, et al.
bioRxiv
. 2024 Jul;
PMID: 39071446
Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) is a new approach for ex vivo genome editing of primary human cells. PERC uses a single amphiphilic peptide reagent to mediate intracellular...
6.
Jung J, Dreyer K, Dray K, Muldoon J, George J, Shirman S, et al.
bioRxiv
. 2024 Jul;
PMID: 39005318
Recent years have seen intense interest in the development of point-of-care nucleic acid diagnostic technologies to address the scaling limitations of laboratory-based approaches. Chief among these are combinations of isothermal...
7.
Chang C, Vykunta V, Goodman D, Muldoon J, Nyberg W, Liu C, et al.
bioRxiv
. 2024 Feb;
PMID: 38370809
Multiplexed reprogramming of T cell specificity and function can generate powerful next-generation cellular therapies. However, current manufacturing methods produce heterogenous mixtures of partially engineered cells. Here, we develop a one-step...
8.
Foss D, Muldoon J, Nguyen D, Carr D, Sahu S, Hunsinger J, et al.
Nat Biomed Eng
. 2023 May;
7(5):647-660.
PMID: 37147433
CRISPR-mediated genome editing of primary human lymphocytes is typically carried out via electroporation, which can be cytotoxic, cumbersome and costly. Here we show that the yields of edited primary human...
9.
Nyberg W, Ark J, To A, Clouden S, Reeder G, Muldoon J, et al.
Cell
. 2023 Jan;
186(2):446-460.e19.
PMID: 36638795
Precise targeting of large transgenes to T cells using homology-directed repair has been transformative for adoptive cell therapies and T cell biology. Delivery of DNA templates via adeno-associated virus (AAV)...
10.
Dray K, Muldoon J, Mangan N, Bagheri N, Leonard J
ACS Synth Biol
. 2022 Mar;
11(4):1699-1704.
PMID: 35271255
No abstract available.