Sriram Krishnaswamy
Overview
Explore the profile of Sriram Krishnaswamy including associated specialties, affiliations and a list of published articles.
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48
Citations
714
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Recent Articles
1.
Kolyadko V, Layzer J, Perry K, Sullenger B, Krishnaswamy S
Proc Natl Acad Sci U S A
. 2024 Jul;
121(29):e2401136121.
PMID: 38985762
Hemostasis relies on a reaction network of serine proteases and their cofactors to form a blood clot. Coagulation factor IXa (protease) plays an essential role in hemostasis as evident from...
2.
Yu H, Kumar S, Frederiksen J, Kolyadko V, Pitoc G, Layzer J, et al.
Nat Commun
. 2024 May;
15(1):3977.
PMID: 38730234
Potent and selective inhibition of the structurally homologous proteases of coagulation poses challenges for drug development. Hematophagous organisms frequently accomplish this by fashioning peptide inhibitors combining exosite and active site...
3.
Muller-Calleja N, Grunz K, Nguyen T, Posma J, Pedrosa D, Meineck M, et al.
Blood
. 2023 Dec;
143(12):1167-1180.
PMID: 38142429
Antiphospholipid antibodies (aPL) in primary or secondary antiphospholipid syndrome (APS) are a major cause for acquired thrombophilia, but specific interventions preventing autoimmune aPL development are an unmet clinical need. Although...
4.
Zhao L, Thorsheim C, Suzuki A, Stalker T, Min S, Krishnaswamy S, et al.
Blood Adv
. 2023 Mar;
7(16):4233-4246.
PMID: 36930803
Platelets use signal transduction pathways facilitated by class I phosphatidylinositol transfer proteins (PITPs). The 2 mammalian class I PITPs, PITPα and PITPβ, are single PITP domain soluble proteins that are...
5.
Soule E, Yu H, Olson L, Naqvi I, Kumar S, Krishnaswamy S, et al.
Cell Chem Biol
. 2022 Feb;
29(2):215-225.e5.
PMID: 35114109
Coagulation cofactors profoundly regulate hemostasis and are appealing targets for anticoagulants. However, targeting such proteins has been challenging because they lack an active site. To address this, we isolate an...
6.
Krishnaswamy S, Ageno W, Arabi Y, Barbui T, Cannegieter S, Carrier M, et al.
Res Pract Thromb Haemost
. 2021 Jul;
5(5):e12532.
PMID: 34296056
This year's Congress of the International Society of Thrombosis and Haemostasis (ISTH) was hosted virtually from Philadelphia July 17-21, 2021. The conference, now held annually, highlighted cutting-edge advances in basic,...
7.
Vadivel K, Schmidt A, Cascio D, Padmanabhan K, Krishnaswamy S, Brandstetter H, et al.
Acta Crystallogr D Struct Biol
. 2021 Jun;
77(Pt 6):809-819.
PMID: 34076594
Coagulation factor VIIa (FVIIa) consists of a γ-carboxyglutamic acid (GLA) domain, two epidermal growth factor-like (EGF) domains and a protease domain. FVIIa binds three Mg ions and four Ca ions...
8.
9.
Basavaraj M, Krishnaswamy S
J Biol Chem
. 2020 Aug;
295(45):15198-15207.
PMID: 32859749
Factor X activation by the intrinsic Xase complex, composed of factor IXa bound to factor VIIIa on membranes, is essential for the amplified blood coagulation response. The biological significance of...
10.
Cines D, Zaitsev S, Rauova L, Rux A, Stepanova V, Krishnaswamy S, et al.
Blood
. 2020 Mar;
135(23):2085-2093.
PMID: 32187355
Thromboembolism complicates disorders caused by immunoglobulin G (IgG)-containing immune complexes (ICs), but the underlying mechanisms are incompletely understood. Prior evidence indicates that induction of tissue factor (TF) on monocytes, a...