Sreenivas Kanugula
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Explore the profile of Sreenivas Kanugula including associated specialties, affiliations and a list of published articles.
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19
Citations
362
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Recent Articles
1.
Kotandeniya D, Rogers M, Fernandez J, Kanugula S, Hudson R, Rodriguez F, et al.
Biopolymers
. 2020 Oct;
112(1):e23405.
PMID: 33098572
Cellular exposure to tobacco-specific nitrosamines causes formation of promutagenic O -[4-oxo-4-(3-pyridyl)but-1-yl]guanine (O -POB-G) and O -methylguanine (O -Me-G) adducts in DNA. These adducts can be directly repaired by O -alkylguanine-DNA...
2.
Kotandeniya D, Murphy D, Yan S, Park S, Seneviratne U, Koopmeiners J, et al.
Biochemistry
. 2013 May;
52(23):4075-88.
PMID: 23683164
Tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N-nitrosonicotine (NNN) are potent carcinogens believed to contribute to the development of lung tumors in smokers. NNK and NNN are metabolized to DNA-reactive species that...
3.
Tretyakova N, Michaelson-Richie E, Gherezghiher T, Kurtz J, Ming X, Wickramaratne S, et al.
Biochemistry
. 2013 Apr;
52(18):3171-81.
PMID: 23566219
Although cytotoxic alkylating agents possessing two electrophilic reactive groups are thought to act by cross-linking cellular biomolecules, their exact mechanisms of action have not been established. In cells, these compounds...
4.
Kotandeniya D, Murphy D, Seneviratne U, Guza R, Pegg A, Kanugula S, et al.
Chem Res Toxicol
. 2011 Sep;
24(11):1966-75.
PMID: 21913712
O(6)-POB-dG (O(6)-[4-oxo-4-(3-pyridyl)but-1-yl]deoxyguanosine) are promutagenic nucleobase adducts that arise from DNA alkylation by metabolically activated tobacco-specific nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N-nitrosonicotine (NNN). If not repaired, O(6)-POB-dG adducts cause mispairing...
5.
Green R, Hanfrey C, Elliott K, McCloskey D, Wang X, Kanugula S, et al.
Mol Microbiol
. 2011 Jul;
81(4):1109-24.
PMID: 21762220
We have identified gene fusions of polyamine biosynthetic enzymes S-adenosylmethionine decarboxylase (AdoMetDC, speD) and aminopropyltransferase (speE) orthologues in diverse bacterial phyla. Both domains are functionally active and we demonstrate the...
6.
Aramini J, Tubbs J, Kanugula S, Rossi P, Ertekin A, Maglaqui M, et al.
J Biol Chem
. 2010 Mar;
285(18):13736-41.
PMID: 20212037
Alkyltransferase-like proteins (ATLs) are a novel class of DNA repair proteins related to O(6)-alkylguanine-DNA alkyltransferases (AGTs) that tightly bind alkylated DNA and shunt the damaged DNA into the nucleotide excision...
7.
Fang Q, Kanugula S, Tubbs J, Tainer J, Pegg A
J Biol Chem
. 2009 Dec;
285(11):8185-95.
PMID: 20026607
O(6)-Alkylguanine-DNA alkyltransferase (AGT) plays a major role in repair of the cytotoxic and mutagenic lesion O(6)-methylguanine (m(6)G) in DNA. Unlike the Escherichia coli alkyltransferase Ogt that also repairs O(4)-methylthymine (m(4)T)...
8.
Tubbs J, Latypov V, Kanugula S, Butt A, Melikishvili M, Kraehenbuehl R, et al.
Nature
. 2009 Jun;
459(7248):808-13.
PMID: 19516334
Alkyltransferase-like proteins (ATLs) share functional motifs with the cancer chemotherapy target O(6)-alkylguanine-DNA alkyltransferase (AGT) and paradoxically protect cells from the biological effects of DNA alkylation damage, despite lacking the reactive...
9.
Philip S, Swaminathan S, Kuznetsov S, Kanugula S, Biswas K, Chang S, et al.
Cancer Res
. 2008 Dec;
68(23):9973-81.
PMID: 19047179
Germ-line mutations in BRCA2 have been linked to early-onset familial breast cancer. BRCA2 is known to play a key role in repairing double-strand breaks. Here, we describe the involvement of...
10.
Mijal R, Kanugula S, Vu C, Fang Q, Pegg A, Peterson L
Cancer Res
. 2006 May;
66(9):4968-74.
PMID: 16651455
The repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT) protects cells from the mutagenic and carcinogenic effects of alkylating agents by removing O(6)-alkylguanine adducts from DNA. Recently, we established that AGT protects against...