Spencer R Rosario
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Explore the profile of Spencer R Rosario including associated specialties, affiliations and a list of published articles.
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27
Citations
168
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Recent Articles
1.
da Silva Fernandes T, Gillard B, Dai T, Martin J, Chaudhry K, Dugas S, et al.
Sci Rep
. 2025 Jan;
15(1):1061.
PMID: 39774345
Triple negative breast cancer (TNBC) is one of the deadliest subtypes of breast cancer, whose high frequency of relapse is often due to resistance to chemotherapy. Here, we identify inosine...
2.
Rosario S, Long M, Chilakapati S, Gomez E, Battaglia S, Singh P, et al.
Nat Commun
. 2024 Dec;
15(1):10609.
PMID: 39638782
Recurrent ovarian cancer patients, especially those resistant to platinum, lack effective curative treatments. To address this, we conducted a phase 2 clinical trial (NCT02853318) combining pembrolizumab with bevacizumab, to increase...
3.
Das A, Barry M, Ernst C, Dahiya R, Kim M, Rosario S, et al.
Commun Biol
. 2024 Nov;
7(1):1545.
PMID: 39572705
Bone metastases occur in the majority of advanced breast cancer patients, and the most common complications are osteolytic bone metastases. However, due to the limitations of models and methodologies for...
4.
Bao R, Hutson A, Madabhushi A, Jonsson V, Rosario S, Barnholtz-Sloan J, et al.
J Immunother Cancer
. 2024 Oct;
12(10).
PMID: 39461879
Immuno-oncology has transformed the treatment of cancer, with several immunotherapies becoming the standard treatment across histologies. Despite these advancements, the majority of patients do not experience durable clinical benefits, highlighting...
5.
Collins C, Khuat L, Sckisel G, Vick L, Minnar C, Dunai C, et al.
Front Immunol
. 2024 Sep;
15():1429912.
PMID: 39315105
The thymus is the central organ involved with T-cell development and the production of naïve T cells. During normal aging, the thymus undergoes marked involution, reducing naïve T-cell output and...
6.
Thiyagarajan R, Zhang L, Glover O, Kwack K, Ahmed S, Murray E, et al.
Aging Cell
. 2024 Aug;
23(11):e14298.
PMID: 39180173
An aged immune system undergoes substantial changes where myelopoiesis dominates within the bone marrow. Monocytic-MDSCs (M-MDSCs) have been found to play an important role in osteoclastogenesis and bone resorption. In...
7.
Oturkar C, Rosario S, Hutson A, Groman A, Edge S, Morrison C, et al.
iScience
. 2024 Jun;
27(6):109995.
PMID: 38868185
The canonical mechanism behind tamoxifen's therapeutic effect on estrogen receptor α/ESR1+ breast cancers is inhibition of ESR1-dependent estrogen signaling. Although ESR1+ tumors expressing wild-type p53 were reported to be more...
8.
Halpert M, Burns B, Rosario S, Withers H, Trivedi A, Hofferek C, et al.
FASEB J
. 2024 May;
38(10):e23644.
PMID: 38738472
Tumors typically lack canonical danger signals required to activate adaptive immunity and also frequently employ substantial immunomodulatory mechanisms that downregulate adaptive responses and contribute to escape from immune surveillance. Given...
9.
Ramakrishnan S, Cortes-Gomez E, Athans S, Attwood K, Rosario S, Kim S, et al.
Genome Med
. 2024 Apr;
16(1):52.
PMID: 38566104
Background: Prostate cancer is a significant health concern, particularly among African American (AA) men who exhibit higher incidence and mortality compared to European American (EA) men. Understanding the molecular mechanisms...
10.
Martin J, da Silva Fernandes T, Chaudhry K, Oshi M, Abrams S, Takabe K, et al.
Sci Rep
. 2024 Mar;
14(1):5731.
PMID: 38459088
Triple-negative breast cancer (TNBC) is one of the most aggressive types of cancer. Despite decades of intense investigation, treatment options remain limited, and rapid recurrence with distant metastases remains a...