Spencer C Knight
Overview
Explore the profile of Spencer C Knight including associated specialties, affiliations and a list of published articles.
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8
Citations
784
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Recent Articles
1.
Kosmicki J, Marcketta A, Sharma D, Di Gioia S, Batista S, Yang X, et al.
Nat Genet
. 2024 Aug;
56(8):1592-1596.
PMID: 39103650
Coronavirus disease 2019 (COVID-19) and influenza are respiratory illnesses caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses, respectively. Both diseases share symptoms and clinical risk...
2.
Knight S, McCurdy S, Rhead B, Coignet M, Park D, Roberts G, et al.
BMJ Open
. 2022 Oct;
12(10):e049657.
PMID: 36223959
Objectives: The enormous toll of the COVID-19 pandemic has heightened the urgency of collecting and analysing population-scale datasets in real time to monitor and better understand the evolving pandemic. The...
3.
Roberts G, Partha R, Rhead B, Knight S, Park D, Coignet M, et al.
Nat Genet
. 2022 Apr;
54(4):374-381.
PMID: 35410379
Multiple COVID-19 genome-wide association studies (GWASs) have identified reproducible genetic associations indicating that there is a genetic component to susceptibility and severity risk. To complement these studies, we collected deep...
4.
Horowitz J, Kosmicki J, Damask A, Sharma D, Roberts G, Justice A, et al.
Nat Genet
. 2022 Mar;
54(4):382-392.
PMID: 35241825
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human host cells via angiotensin-converting enzyme 2 (ACE2) and causes coronavirus disease 2019 (COVID-19). Here, through a genome-wide association study, we identify...
5.
Knight S, Tjian R, Doudna J
Angew Chem Int Ed Engl
. 2017 Oct;
57(16):4329-4337.
PMID: 29080263
The discovery of the CRISPR-Cas9 endonuclease has enabled facile genome editing in living cells and organisms. Catalytically inactive Cas9 (dCas9) retains the ability to bind DNA in an RNA-guided fashion,...
6.
East-Seletsky A, OConnell M, Knight S, Burstein D, Cate J, Tjian R, et al.
Nature
. 2016 Sep;
538(7624):270-273.
PMID: 27669025
Bacterial adaptive immune systems use CRISPRs (clustered regularly interspaced short palindromic repeats) and CRISPR-associated (Cas) proteins for RNA-guided nucleic acid cleavage. Although most prokaryotic adaptive immune systems generally target DNA...
7.
Knight S, Xie L, Deng W, Guglielmi B, Witkowsky L, Bosanac L, et al.
Science
. 2015 Nov;
350(6262):823-6.
PMID: 26564855
The RNA-guided CRISPR-associated protein Cas9 is used for genome editing, transcriptional modulation, and live-cell imaging. Cas9-guide RNA complexes recognize and cleave double-stranded DNA sequences on the basis of 20-nucleotide RNA-DNA...
8.
Pietrangelo A, Knight S, Gupta A, Yao L, Hillmyer M, Tolman W
J Am Chem Soc
. 2010 Aug;
132(33):11649-57.
PMID: 20672812
We report the results of a comprehensive investigation of the recently discovered stereoselective and controlled polymerization of racemic lactide (D,L-LA) using an initiator prepared in situ from indium(III) chloride (InCl(3)),...