Spencer C Cushen
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Explore the profile of Spencer C Cushen including associated specialties, affiliations and a list of published articles.
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15
Citations
97
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Recent Articles
1.
Gardner J, Cushen S, da Silva R, Bradshaw J, Hula N, Gorham I, et al.
Am J Physiol Cell Physiol
. 2024 May;
326(6):C1776-C1788.
PMID: 38738304
Circulating cell-free mitochondrial DNA (ccf-mtDNA) is an indicator of cell death, inflammation, and oxidative stress. ccf-mtDNA in pregnancies with placental dysfunction differs from that in healthy pregnancies, and the direction...
2.
Gardner J, Cushen S, da Silva R, Bradshaw J, Hula N, Gorham I, et al.
bioRxiv
. 2024 Feb;
PMID: 38352590
New & Noteworthy: This is the first study to test whether trophoblast cells release mitochondrial DNA in response to oxidative stress and to identify mechanisms of release and biological forms...
3.
Mabry S, Wilson E, Bradshaw J, Gardner J, Fadeyibi O, Vera Jr E, et al.
Biol Sex Differ
. 2023 Nov;
14(1):81.
PMID: 37951901
Background: Gestational sleep apnea is a hypoxic sleep disorder that affects 8-26% of pregnancies and increases the risk for central nervous system dysfunction in offspring. Specifically, there are sex differences...
4.
Bradshaw J, Cushen S, Ricci C, Tucker S, Gardner J, Little J, et al.
Am J Physiol Heart Circ Physiol
. 2023 Jun;
325(2):H323-H337.
PMID: 37352412
Bacterial infections and impaired circulating mitochondrial DNA dynamics are associated with adverse pregnancy outcomes. Unmethylated cytosine-guanine dinucleotide (CpG) motifs are common in bacterial and mitochondrial DNA and act as potent...
5.
Mabry S, Wilson E, Bradshaw J, Gardner J, Fadeyibi O, Vera Jr E, et al.
Res Sq
. 2023 Jun;
PMID: 37333114
Background: Gestational sleep apnea affects 8-26% of pregnancies and can increase the risk for autism spectrum disorder (ASD) in offspring. ASD is a neurodevelopmental disorder associated with social dysfunction, repetitive...
6.
Bradshaw J, Cushen S, Ricci C, Tucker S, Gardner J, Little J, et al.
bioRxiv
. 2023 Mar;
PMID: 36993698
Bacterial infections and impaired mitochondrial DNA dynamics are associated with adverse pregnancy outcomes. Unmethylated cytosine-guanine dinucleotide (CpG) motifs are common in bacterial and mitochondrial DNA and act as potent immunostimulators....
7.
Wilson E, Mabry S, Bradshaw J, Gardner J, Rybalchenko N, Engelland R, et al.
Biol Sex Differ
. 2022 Sep;
13(1):54.
PMID: 36175941
Background: Hypoxia is associated with pregnancy complications, such as preeclampsia, placental abruption, and gestational sleep apnea. Hypoxic insults during gestation can impact the brain maturation of cortical and subcortical pathways,...
8.
Osikoya O, Cushen S, Gardner J, Raetz M, Nagarajan B, Raut S, et al.
Am J Physiol Heart Circ Physiol
. 2022 Jul;
323(3):H577-H584.
PMID: 35904885
Perivascular adipose tissue (PVAT) is distinct from other adipose depots, as it has differential gene and protein profiles and vasoactive functions. We have shown that pregnancy affects the morphology of...
9.
Cushen S, Ricci C, Bradshaw J, Silzer T, Blessing A, Sun J, et al.
J Am Heart Assoc
. 2022 Jan;
11(2):e021726.
PMID: 35014857
Background Circulating cell-free mitochondrial DNA (ccf-mtDNA) is a damage-associated molecular pattern that reflects cell stress responses and tissue damage, but little is known about ccf-mtDNA in preeclampsia. The main objectives...
10.
Bradshaw J, Cushen S, Phillips N, Goulopoulou S
Physiology (Bethesda)
. 2022 Jan;
37(4).
PMID: 35001655
Circulating cell-free mitochondrial DNA (ccf-mtDNA) released upon cell injury or death stimulates diverse pattern recognition receptors to activate innate immune responses and initiate systemic inflammation. In this review, we discuss...