Soren Brogger Christensen
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Explore the profile of Soren Brogger Christensen including associated specialties, affiliations and a list of published articles.
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44
Citations
725
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Recent Articles
1.
Christensen S
Molecules
. 2022 Sep;
27(17).
PMID: 36080414
During a screening performed by the National Cancer Institute in the 1960s, the terpenoid paclitaxel was discovered. Paclitaxel expanded the treatment options for breast, lung, prostate and ovarian cancer. Paclitaxel...
2.
Isaacs J, Brennen W, Christensen S, Denmeade S
Molecules
. 2021 Dec;
26(24).
PMID: 34946547
Søren Brøgger Christensen isolated and characterized the cell-penetrant sesquiterpene lactone Thapsigargin (TG) from the fruit In the late 1980s/early 1990s, TG was supplied to multiple independent and collaborative groups. Using...
3.
Christensen S
Molecules
. 2021 Oct;
26(19).
PMID: 34641601
The appearance of antibiotic drugs revolutionized the possibilities for treatment of diseases with high mortality such as pneumonia, sepsis, plaque, diphtheria, tetanus, typhoid fever, and tuberculosis. Today fewer than 1%...
4.
Christensen S
Biomedicines
. 2021 Apr;
9(5).
PMID: 33925870
Until the end of the 19th century all drugs were natural products or minerals. During the 19th century chemists succeeded in isolating pure natural products such as quinine, morphine, codeine...
5.
Christensen S, Simonsen H, Engedal N, Nissen P, Moller J, Denmeade S, et al.
Prog Chem Org Nat Prod
. 2021 Apr;
115:59-114.
PMID: 33797641
Thapsigargin, the first representative of the hexaoxygenated guaianolides, was isolated 40 years ago in order to understand the skin-irritant principles of the resin of the umbelliferous plant Thapsia garganica. The...
6.
Franzyk H, Christensen S
Molecules
. 2021 Mar;
26(5).
PMID: 33673582
Many cancer diseases, e.g., prostate cancer and lung cancer, develop very slowly. Common chemotherapeutics like vincristine, vinblastine and taxol target cancer cells in their proliferating states. In slowly developing cancer...
7.
Zimmermann T, Drasar P, Rimpelova S, Christensen S, Khripach V, Jurasek M
Biomolecules
. 2020 Dec;
10(12).
PMID: 33291419
In spite of the impressing cytotoxicity of thapsigargin (), this compound cannot be used as a chemotherapeutic drug because of general toxicity, causing unacceptable side effects. Instead, a prodrug targeted...
8.
Tarvainen I, Zimmermann T, Heinonen P, Jantti M, Yli-Kauhaluoma J, Talman V, et al.
ACS Med Chem Lett
. 2020 May;
11(5):671-677.
PMID: 32435369
Targeting cytotoxic 4β-phorbol esters toward cancer tissue was attempted by conjugating a 4β-pborbol derivative with substrates for the proteases prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSMA) expressed in cancer...
9.
Lindner P, Christensen S, Nissen P, Moller J, Engedal N
Cell Commun Signal
. 2020 Jan;
18(1):12.
PMID: 31987044
Background: Cell death triggered by unmitigated endoplasmic reticulum (ER) stress plays an important role in physiology and disease, but the death-inducing signaling mechanisms are incompletely understood. To gain more insight...
10.
Andersen T, Rasmussen S, Christensen S, Simonsen H
Phytochemistry
. 2018 Nov;
157:168-174.
PMID: 30412824
The genus Thapsia produces a wide variety of sesquiterpenoids. The Mediterranean plant Thapsia laciniata Rouy is known to have a product profile that differs from several other species in the...