Sophie Schobesberger
Overview
Explore the profile of Sophie Schobesberger including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
339
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Recent Articles
1.
Sanchez-Alonso J, Loucks A, Schobesberger S, van Cromvoirt A, Poulet C, Chowdhury R, et al.
EBioMedicine
. 2020 Jun;
57:102845.
PMID: 32580140
Background: Subcellular localization and function of L-type calcium channels (LTCCs) play an important role in regulating contraction of cardiomyocytes. Understanding how this is affected by the disruption of transverse tubules...
2.
Schobesberger S, Wright P, Poulet C, Sanchez Alonso Mardones J, Mansfield C, Friebe A, et al.
Elife
. 2020 Apr;
9.
PMID: 32228862
Cardiomyocyte β-adrenoceptors (β-ARs) coupled to soluble guanylyl cyclase (sGC)-dependent production of the second messenger 3',5'-cyclic guanosine monophosphate (cGMP) have been shown to protect from heart failure. However, the exact localization...
3.
Stathopoulou K, Schobesberger S, Bork N, Sprenger J, Perera R, Sotoud H, et al.
Cell Signal
. 2019 Jul;
63:109362.
PMID: 31344438
P90 ribosomal S6 kinases (RSK) are ubiquitously expressed and regulate responses to neurohumoral stimulation. To study the role of RSK signalling on cardiac myocyte function and protein phosphorylation, pharmacological RSK...
4.
Wright P, Bhogal N, Diakonov I, Pannell L, Perera R, Bork N, et al.
Cell Rep
. 2018 Apr;
23(2):459-469.
PMID: 29642004
Cardiomyocytes from the apex but not the base of the heart increase their contractility in response to β-adrenoceptor (βAR) stimulation, which may underlie the development of Takotsubo cardiomyopathy. However, both...
5.
Flenner F, Arlt N, Nasib M, Schobesberger S, Koch T, Ravens U, et al.
Anesthesiology
. 2018 Mar;
128(6):1175-1186.
PMID: 29547406
Background: Systemic toxicity of local anesthetics is predominantly complicated by their myocardial toxicity. Especially long-acting local anesthetics exert a negative inotropic effect that has been described at lower concentrations than...
6.
Donzelli S, Goetz M, Schmidt K, Wolters M, Stathopoulou K, Diering S, et al.
Sci Rep
. 2017 Sep;
7(1):9938.
PMID: 28855531
Despite the mechanisms for endogenous nitroxyl (HNO) production and action being incompletely understood, pharmacological donors show broad therapeutic promise and are in clinical trials. Mass spectrometry and site-directed mutagenesis showed...
7.
Schobesberger S, Wright P, Tokar S, Bhargava A, Mansfield C, Glukhov A, et al.
Cardiovasc Res
. 2017 May;
113(7):770-782.
PMID: 28505272
Aims: Cardiomyocyte β2-adrenergic receptor (β2AR) cyclic adenosine monophosphate (cAMP) signalling is regulated by the receptors' subcellular location within transverse tubules (T-tubules), via interaction with structural and regulatory proteins, which form...
8.
Sanchez-Alonso J, Bhargava A, OHara T, Glukhov A, Schobesberger S, Bhogal N, et al.
Circ Res
. 2016 Aug;
119(8):944-55.
PMID: 27572487
Rationale: Disruption in subcellular targeting of Ca(2+) signaling complexes secondary to changes in cardiac myocyte structure may contribute to the pathophysiology of a variety of cardiac diseases, including heart failure...
9.
Schobesberger S, Jonsson P, Buzuk A, Korchev Y, Siggers J, Gorelik J
Biophys J
. 2016 Jan;
110(1):141-6.
PMID: 26745417
With scanning ion conductance microscopy (SICM), a noncontact scanning probe technique, it is possible both to obtain information about the surface topography of live cells and to apply molecules onto...
10.
Miragoli M, Sanchez-Alonso J, Bhargava A, Wright P, Sikkel M, Schobesberger S, et al.
Cell Rep
. 2016 Jan;
14(1):140-151.
PMID: 26725114
Arrhythmogenesis during heart failure is a major clinical problem. Regional electrical gradients produce arrhythmias, and cellular ionic transmembrane gradients are its originators. We investigated whether the nanoscale mechanosensitive properties of...