Sophie E Broughton
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Explore the profile of Sophie E Broughton including associated specialties, affiliations and a list of published articles.
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20
Citations
563
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Recent Articles
1.
Kan W, Dhagat U, Kaufmann K, Hercus T, Nero T, Zeng A, et al.
Cancer Discov
. 2023 May;
13(8):1922-1947.
PMID: 37191437
Significance: Stemness is a hallmark of many cancers and is largely responsible for disease emergence, progression, and relapse. Our finding that clinically significant stemness programs in AML are directly regulated...
2.
Broughton S, ONeill D, Syme H, Geddes R
J Vet Intern Med
. 2023 Jan;
37(1):80-91.
PMID: 36645022
Background: Ionized calcium concentration ([iCa]) is more sensitive for detecting calcium disturbances than serum total calcium concentration but literature on ionized hypercalcemia in cats is limited. Urolithiasis is a possible...
3.
Cheung Tung Shing K, Broughton S, Nero T, Gillinder K, Ilsley M, Ramshaw H, et al.
Sci Rep
. 2019 May;
9(1):7851.
PMID: 31110193
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
4.
Cheung Tung Shing K, Broughton S, Nero T, Gillinder K, Ilsley M, Ramshaw H, et al.
Sci Rep
. 2018 Aug;
8(1):12457.
PMID: 30127368
A direct interaction between the erythropoietin (EPOR) and the beta-common (βc) receptors to form an Innate Repair Receptor (IRR) is controversial. On one hand, studies have shown a functional link...
5.
Dhagat U, Hercus T, Broughton S, Nero T, Cheung Tung Shing K, Barry E, et al.
MAbs
. 2018 Jul;
10(7):1018-1029.
PMID: 29969365
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that can stimulate a variety of cells, but its overexpression leads to excessive production and activation of granulocytes and macrophages with...
6.
Broughton S, Hercus T, Nero T, Kan W, Barry E, Dottore M, et al.
Nat Commun
. 2018 Jan;
9(1):386.
PMID: 29374162
The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the haemopoietic, vascular and immune systems and is overexpressed in acute and chronic myeloid leukaemia progenitor cells. It belongs to...
7.
Hercus T, Kan W, Broughton S, Tvorogov D, Ramshaw H, Sandow J, et al.
Cold Spring Harb Perspect Biol
. 2017 Jul;
10(6).
PMID: 28716883
The β common ([βc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which use βc as their key signaling receptor subunit. This is...
8.
Broughton S, Hercus T, Nero T, Dottore M, McClure B, Dhagat U, et al.
Structure
. 2016 Jul;
24(8):1271-1281.
PMID: 27396825
The GM-CSF, IL-3, and IL-5 receptors constitute the βc family, playing important roles in inflammation, autoimmunity, and cancer. Typical of heterodimeric type I cytokine receptors, signaling requires recruitment of the...
9.
Hercus T, Broughton S, Hardy M, Nero T, Wilson N, Parker M, et al.
Mol Cell Oncol
. 2016 Jun;
1(4):e969129.
PMID: 27308368
CSL362 is a humanized interleukin-3 (IL-3)-neutralizing monoclonal antibody with enhanced effector function that binds the α subunit of the IL-3 receptor (IL3Rα). The crystal structure of an IL3Rα:CSL362 complex shows...
10.
Broughton S, Nero T, Dhagat U, Kan W, Hercus T, Tvorogov D, et al.
Cytokine
. 2015 May;
74(2):247-58.
PMID: 25982846
Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5 are members of a small family of cytokines that share a beta receptor subunit (βc). These cytokines regulate the growth, differentiation, migration...