Sophie C Lodestijn
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Explore the profile of Sophie C Lodestijn including associated specialties, affiliations and a list of published articles.
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9
Citations
151
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Recent Articles
1.
Dings M, Manoukian P, Waasdorp C, Quik J, Strijker M, Lodestijn S, et al.
Int J Cancer
. 2022 Sep;
152(3):511-523.
PMID: 36069222
Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma, the main cellular constituents of which are cancer-associated fibroblasts (CAFs). Stroma-targeting agents have been proposed to improve the poor outcome of...
2.
Lodestijn S, Miedema D, Lenos K, Nijman L, Belt S, El Makrini K, et al.
Cell Rep
. 2021 Oct;
37(3):109852.
PMID: 34686335
Effective treatments for pancreatic ductal adenocarcinoma (PDAC) are lacking, and targeted agents have demonstrated limited efficacy. It has been speculated that a rare population of cancer stem cells (CSCs) drives...
3.
Lodestijn S, van den Bosch T, Nijman L, Moreno L, Schlingemann S, Sheraton V, et al.
Cell Stem Cell
. 2021 Aug;
28(11):2009-2019.e4.
PMID: 34358441
The tissue dynamics that govern maintenance and regeneration of the pancreas remain largely unknown. In particular, the presence and nature of a cellular hierarchy remains a topic of debate. Previous...
4.
Lodestijn S, van Neerven S, Vermeulen L, Bijlsma M
Cancers (Basel)
. 2021 Jul;
13(13).
PMID: 34209288
Cell generation and renewal are essential processes to develop, maintain, and regenerate tissues. New cells can be generated from immature cell types, such as stem-like cells, or originate from more...
5.
Tekin C, Scicluna B, Lodestijn S, Shi K, Bijlsma M, Spek C
Mol Oncol
. 2021 May;
15(11):3091-3108.
PMID: 33932087
Pancreatic acinar cells have high plasticity and can transdifferentiate into ductal-like cells. This acinar-to-ductal metaplasia (ADM) contributes to tissue maintenance but may also contribute to the premalignant transformation that can...
6.
Lenos K, Lodestijn S, Lyons S, Bijlsma M, Miedema D, Vermeulen L
Nat Protoc
. 2019 Aug;
14(9):2648-2671.
PMID: 31420599
Lineage tracing is a powerful tool that can be used to uncover cell fates. Here, we describe a novel method for the quantitative analysis of clonal dynamics in grafted cancer...
7.
van der Heijden M, Miedema D, Waclaw B, Veenstra V, Lecca M, Nijman L, et al.
Proc Natl Acad Sci U S A
. 2019 Mar;
116(13):6140-6145.
PMID: 30850544
Cancer evolution is predominantly studied by focusing on differences in the genetic characteristics of malignant cells within tumors. However, the spatiotemporal dynamics of clonal outgrowth that underlie evolutionary trajectories remain...
8.
Lodestijn S, Lenos K, Miedema D, Bijlsma M, Vermeulen L
Mol Cell Oncol
. 2019 Feb;
6(1):1540235.
PMID: 30788417
By using marker-free lineage tracing in combination with quantitative analysis, we recently revealed cancer stem cell functionality in established human colon cancer is not intrinsically defined, but fully spatiotemporally regulated.
9.
Lenos K, Miedema D, Lodestijn S, Nijman L, van den Bosch T, Ros X, et al.
Nat Cell Biol
. 2018 Sep;
20(10):1193-1202.
PMID: 30177776
Solid malignancies have been speculated to depend on cancer stem cells (CSCs) for expansion and relapse after therapy. Here we report on quantitative analyses of lineage tracing data from primary...