Sophie Barbe
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Explore the profile of Sophie Barbe including associated specialties, affiliations and a list of published articles.
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42
Citations
405
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Recent Articles
11.
Zhao J, Tandrup T, Bissaro B, Barbe S, Poulsen J, Andre I, et al.
N Biotechnol
. 2021 Feb;
62:68-78.
PMID: 33524585
The use of retaining glycoside hydrolases as synthetic tools for glycochemistry is highly topical and the focus of considerable research. However, due to the incomplete identification of the molecular determinants...
12.
Bourlieu C, Astruc T, Barbe S, Berrin J, Bonnin E, Boutrou R, et al.
Biotechnol Adv
. 2020 Apr;
41:107546.
PMID: 32275940
Enzymes are essential and ubiquitous biocatalysts involved in various metabolic pathways and used in many industrial processes. Here, we reframe enzymes not just as biocatalysts transforming bioproducts but also as...
13.
Vucinic J, Simoncini D, Ruffini M, Barbe S, Schiex T
Bioinformatics
. 2019 Jun;
36(1):122-130.
PMID: 31199465
Motivation: Structure-based computational protein design (CPD) plays a critical role in advancing the field of protein engineering. Using an all-atom energy function, CPD tries to identify amino acid sequences that...
14.
Simoncini D, Zhang K, Schiex T, Barbe S
Bioinformatics
. 2018 Nov;
35(14):2418-2426.
PMID: 30496341
Motivation: Structure-based Computational Protein design (CPD) plays a critical role in advancing the field of protein engineering. Using an all-atom energy function, CPD tries to identify amino acid sequences that...
15.
Charpentier A, Mignon D, Barbe S, Cortes J, Schiex T, Simonson T, et al.
J Chem Inf Model
. 2018 Nov;
59(1):127-136.
PMID: 30380857
Computational protein design (CPD) aims to predict amino acid sequences that fold to specific structures and perform desired functions. CPD depends on a rotamer library, an energy function, and an...
16.
Viricel C, de Givry S, Schiex T, Barbe S
Bioinformatics
. 2018 Feb;
34(15):2581-2589.
PMID: 29474517
Motivation: Accurate and economic methods to predict change in protein binding free energy upon mutation are imperative to accelerate the design of proteins for a wide range of applications. Free...
17.
Verges A, Barbe S, Cambon E, Moulis C, Tranier S, Remaud-Simeon M, et al.
Carbohydr Polym
. 2017 Jul;
173:403-411.
PMID: 28732882
Amylosucrase from Neisseria polysaccharea naturally catalyzes the synthesis of α-1,4 glucans from sucrose. The product profile is quite polydisperse, ranging from soluble chains called maltooligosaccharides to high-molecular weight insoluble amylose....
18.
Rigouin C, Gueroult M, Croux C, Dubois G, Borsenberger V, Barbe S, et al.
ACS Synth Biol
. 2017 Jun;
6(10):1870-1879.
PMID: 28585817
Yarrowia lipolytica is a promising organism for the production of lipids of biotechnological interest and particularly for biofuel. In this study, we engineered the key enzyme involved in lipid biosynthesis,...
19.
Decout A, Silva-Gomes S, Drocourt D, Barbe S, Andre I, Cueto F, et al.
Proc Natl Acad Sci U S A
. 2017 Feb;
114(10):2675-2680.
PMID: 28223515
The advances in subunit vaccines development have intensified the search for potent adjuvants, particularly adjuvants inducing cell-mediated immune responses. Identification of the C-type lectin Mincle as one of the receptors...
20.
Verges A, Cambon E, Barbe S, Moulis C, Remaud-Simeon M, Andre I
Protein Sci
. 2016 Dec;
26(3):566-577.
PMID: 28019698
A computer-aided engineering approach recently enabled to deeply reshape the active site of N. polysaccharea amylosucrase for recognition of non-natural acceptor substrates. Libraries of variants were constructed and screened on...