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Sophana Chea

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Citations 223
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Recent Articles
1.
Brooks S, Ruhl A, Zeng X, Cruz P, Hassan S, Kamenyeva O, et al.
Circulation . 2024 Dec; 151(1):8-30. PMID: 39633569
Background: Severe malaria is associated with impaired nitric oxide (NO) synthase (NOS)-dependent vasodilation, and reversal of this deficit improves survival in murine models. Malaria might have selected for genetic polymorphisms...
2.
Fathi P, Alfonso A, Yek C, Putman Z, Drew M, Esposito D, et al.
Adv Sci (Weinh) . 2024 Oct; 12(1):e2403503. PMID: 39471070
Dynamic pathogen exposure may impact the immunological response to SARS-CoV-2 (SCV2). One potential explanation for the lack of severe SCV2-related morbidity and mortality in Southeast Asia is prior exposure to...
3.
Odio C, Yek C, Hasund C, Man S, Ly P, Nhek S, et al.
J Infect Dis . 2024 Sep; 231(2):e337-e344. PMID: 39297691
Background: Seroprevalence studies are the standard for disease surveillance, and serology determined eligibility for the first dengue vaccine. Expanding flavivirus co-circulation and vaccination complicate testing. We evaluate the accuracy of...
4.
Brook C, Rozins C, Bohl J, Ahyong V, Chea S, Fahsbender L, et al.
Proc Natl Acad Sci U S A . 2024 Aug; 121(36):e2318704121. PMID: 39190356
The incidence of dengue virus disease has increased globally across the past half-century, with highest number of cases ever reported in 2019 and again in 2023. We analyzed climatological, epidemiological,...
5.
Yek C, Lon C, Chea S, Lay S, Oum M, Tang G, et al.
J Infect Dis . 2024 Aug; PMID: 39163245
Background: Antimicrobial resistance (AMR) surveillance in low- and middle-income countries (LMICs) often relies on poorly resourced laboratory processes. Centralized sequencing was combined with cloud-based, open-source bioinformatics solutions for national AMR...
6.
Pacheco A, Chea S, Saunders H, Ly S, Sath R, Tim R, et al.
Am J Trop Med Hyg . 2024 Jun; 111(2):277-280. PMID: 38889712
In resource-scarce settings, melioidosis is associated with up to 80% mortality. Studies of melioidosis in Cambodia report primarily on pediatric populations with localized infection; however, literature describing Cambodian adults with...
7.
Chea S, Willen L, Nhek S, Ly P, Tang K, Oristian J, et al.
Front Immunol . 2024 May; 15:1368066. PMID: 38751433
Introduction: are the most prolific mosquito vectors in the world. Found on every continent, they can effectively transmit various arboviruses, including the dengue virus which continues to cause outbreaks worldwide...
8.
Chea S, Willen L, Nhek S, Ly P, Tang K, Oristian J, et al.
medRxiv . 2024 Feb; PMID: 38318204
Introduction: are the most prolific mosquito vectors in the world. Found on every continent, they can effectively transmit various arboviruses, including the dengue virus which continues to cause outbreaks worldwide...
9.
Odio C, Yek C, Hasund C, Man S, Ly P, Nhek S, et al.
medRxiv . 2023 Dec; PMID: 38076831
Seroprevalence studies are the gold standard for disease surveillance, and serology was used to determine eligibility for the first licensed dengue vaccine. However, expanding flavivirus endemicity, co-circulation, and vaccination complicate...
10.
Yek C, Li Y, Pacheco A, Lon C, Duong V, Dussart P, et al.
Bull World Health Organ . 2023 Aug; 101(9):605-616. PMID: 37638355
Global dengue incidence has increased dramatically over the past few decades from approximately 500 000 reported cases in 2000 to over 5 million in 2019. This trend has been attributed...