Soo Han Bae
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Explore the profile of Soo Han Bae including associated specialties, affiliations and a list of published articles.
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46
Citations
5713
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Recent Articles
31.
Park J, Kang D, Lee D, Bae S
Biochem Biophys Res Commun
. 2015 Sep;
466(3):499-504.
PMID: 26381178
p70 ribosomal S6 kinase 1 (S6K1) is an important serine/threonine kinase and downstream target of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway. PF-4708671 is a specific inhibitor...
32.
Park J, Kang D, Lee D, Bae S
Biochem Biophys Res Commun
. 2015 Sep;
466(1):131-7.
PMID: 26325428
Nonalcoholic fatty liver disease (NAFLD), frequently associated with obesity and diabetes mellitus, is caused by the accumulation of excess fatty acids within liver cells. Palmitic acid (PA), a common saturated...
33.
Park J, Kang D, Lee D, Bae S
Biochem Biophys Res Commun
. 2015 Aug;
465(3):542-7.
PMID: 26282199
Peroxisome proliferator-activated receptor α (PPARα) activates the β-oxidation of fatty acids in the liver. Fenofibrate is a potent agonist of PPARα and is used in the treatment of hyperlipidemia. Fenofibrate...
34.
Park J, Kang D, Bae S
Biochem Biophys Res Commun
. 2015 Jul;
464(4):1139-1144.
PMID: 26208452
Carbonyl cyanide m-chlorophenyl hydrazone (CCCP) is a mitochondrial depolarizing agent that induces reactive oxygen species (ROS)-mediated cell death. The Nrf2-Keap1 pathway is crucial for the elimination of ROS in stressed...
35.
Rhee S, Bae S
Free Radic Biol Med
. 2015 Jun;
88(Pt B):205-211.
PMID: 26117317
Sestrins 1 to 3 constitute a family of proteins that are induced in mammalian cells in response to environmental stressors. Despite their apparent lack of intrinsic catalytic antioxidant activity, Sestrins...
36.
Kil I, Bae S, Rhee S
Methods Enzymol
. 2013 Jul;
527:169-81.
PMID: 23830631
Members of the peroxiredoxin (Prx) family of antioxidant enzymes are inactivated via hyperoxidation of the active site cysteine by the substrate H2O2 and are reactivated via an ATP-consuming process catalyzed...
37.
Bae S, Sung S, Oh S, Lim J, Lee S, Park Y, et al.
Cell Metab
. 2013 Jan;
17(1):73-84.
PMID: 23274085
Sestrins (Sesns) protect cells from oxidative stress. The mechanism underlying the antioxidant effect of Sesns has remained unknown, however. The Nrf2-Keap1 pathway provides cellular defense against oxidative stress by controlling...
38.
Kil I, Lee S, Ryu K, Woo H, Hu M, Bae S, et al.
Mol Cell
. 2012 Jun;
46(5):584-94.
PMID: 22681886
Certain members of the peroxiredoxin (Prx) family undergo inactivation through hyperoxidation of the catalytic cysteine to sulfinic acid during catalysis and are reactivated by sulfiredoxin; however, the physiological significance of...
39.
Jeong W, Bae S, Toledano M, Rhee S
Free Radic Biol Med
. 2012 May;
53(3):447-56.
PMID: 22634055
Peroxiredoxins (Prxs) constitute a family of peroxidases in which cysteine serves as the primary site of oxidation during the reduction of peroxides. Members of the 2-Cys Prx subfamily of Prxs...
40.
Bae S, Sung S, Lee H, Kang H, Lee S, Oh S, et al.
Antioxid Redox Signal
. 2012 Apr;
17(10):1351-61.
PMID: 22490042
Aims: To define the mechanisms underlying pyrazole-induced oxidative stress and the protective role of peroxiredoxins (Prxs) and sulfiredoxin (Srx) against such stress. Results: Pyrazole increased Srx expression in the liver...