Sonke Friedrichsen
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Explore the profile of Sonke Friedrichsen including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
334
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Recent Articles
1.
Evers M, Brandl B, Rohrandt C, Kubelt-Kwamin C, Muller F, Danso D, et al.
Comput Struct Biotechnol J
. 2024 Nov;
26:51-57.
PMID: 39606159
Currently, central nervous system tumors are diagnosed with an integrated diagnostic approach that combines histopathological examination with molecular genetic profiling, which requires days to weeks to achieve a precise and...
2.
Harper C, Finkenstadt B, Woodcock D, Friedrichsen S, Semprini S, Ashall L, et al.
PLoS Biol
. 2011 May;
9(4):e1000607.
PMID: 21532732
In individual mammalian cells the expression of some genes such as prolactin is highly variable over time and has been suggested to occur in stochastic pulses. To investigate the origins...
3.
Giles A, Madec F, Friedrichsen S, Featherstone K, Chambers T, Harper C, et al.
J Cell Sci
. 2011 Jan;
124(Pt 4):540-7.
PMID: 21245194
Prolactinomas are the most common type of functioning pituitary adenoma in humans, but the control of lactotroph proliferation remains unclear. Here, using microarray analysis, we show that estrogen treatment increased...
4.
Harper C, Featherstone K, Semprini S, Friedrichsen S, McNeilly J, Paszek P, et al.
J Cell Sci
. 2010 Feb;
123(Pt 3):424-30.
PMID: 20130141
Gene expression in living cells is highly dynamic, but temporal patterns of gene expression in intact tissues are largely unknown. The mammalian pituitary gland comprises several intermingled cell types, organised...
5.
Mittag J, Friedrichsen S, Strube A, Heuer H, Bauer K
Endocrinology
. 2009 May;
150(9):4443-9.
PMID: 19477936
Thyroid hormone is important for pituitary development and maintenance. We previously reported that in the Pax8(-/-) mouse model of congenital hypothyroidism, lactotrophs are almost undetectable, whereas the thyrotrophs exhibit hyperplasia...
6.
Semprini S, Friedrichsen S, Harper C, McNeilly J, Adamson A, Spiller D, et al.
Mol Endocrinol
. 2009 Jan;
23(4):529-38.
PMID: 19147700
We have generated a humanized double-reporter transgenic rat for whole-body in vivo imaging of endocrine gene expression, using the human prolactin (PRL) gene locus as a physiologically important endocrine model...
7.
Makwana M, Jones L, Cuthill D, Heuer H, Bohatschek M, Hristova M, et al.
J Neurosci
. 2007 Oct;
27(42):11201-13.
PMID: 17942715
Transforming growth factor beta1 (TGFbeta1) is a pleiotropic cytokine with potent neurotrophic and immunosuppressive properties that is upregulated after injury, but also expressed in the normal nervous system. In the...
8.
Friedrichsen S, Harper C, Semprini S, Wilding M, Adamson A, Spiller D, et al.
Endocrinology
. 2005 Oct;
147(2):773-81.
PMID: 16254029
Pituitary function has been shown to be regulated by an increasing number of intrapituitary factors, including cytokines. Here we show that the important cytokine TNF-alpha activates prolactin gene transcription in...
9.
Friedrichsen S, Heuer H, Christ S, Cuthill D, Bauer K, Raivich G
Growth Factors
. 2005 Jul;
23(1):43-53.
PMID: 16019426
The connective tissue growth factor (CTGF) is a well-known fibroblast mitogen and angiogenic factor that plays an important role in bone formation during embryogenesis. In the adult, CTGF is involved...
10.
Mittag J, Friedrichsen S, Heuer H, Polsfuss S, Visser T, Bauer K
Endocrinology
. 2005 Apr;
146(7):3179-84.
PMID: 15802493
The Pax8(-/-) mouse provides an ideal animal model to study the consequences of congenital hypothyroidism, because its only known defect is the absence of thyroid follicular cells. Pax8(-/-) mice are,...