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Soledad Negrotto

Explore the profile of Soledad Negrotto including associated specialties, affiliations and a list of published articles. Areas
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Articles 34
Citations 809
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Recent Articles
11.
Winter U, Buitrago E, Mena H, Del Sole M, Laurent V, Negrotto S, et al.
Invest Ophthalmol Vis Sci . 2015 Jul; 56(8):4382-93. PMID: 26176875
Purpose: To assess in vitro cytotoxic activity and antiangiogenic effect, ocular and systemic disposition, and toxicity of digoxin in rabbits after intravitreal injection as a potential candidate for retinoblastoma treatment....
12.
Negrotto S, Mena H, Ure A, Jaquenod De Giusti C, Bollati-Fogolin M, Vermeulen E, et al.
J Virol . 2015 May; 89(14):7409-13. PMID: 25926646
The arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are...
13.
Mena H, Lokajczyk A, Dizier B, Strier S, Voto L, Boisson-Vidal C, et al.
Angiogenesis . 2014 May; 17(4):867-79. PMID: 24854678
Objective: Acidosis is present in several pathological conditions where vasculogenesis takes place including ischemia, tumor growth and wound healing. We have previously demonstrated that acidosis induces human CD34+ cell apoptosis....
14.
Etulain J, Negrotto S, Tribulatti M, Croci D, Carabelli J, Campetella O, et al.
PLoS One . 2014 May; 9(4):e96402. PMID: 24788652
Platelets contribute to vessel formation through the release of angiogenesis-modulating factors stored in their α-granules. Galectins, a family of lectins that bind β-galactoside residues, are up-regulated in inflammatory and cancerous...
15.
Rivadeneyra L, Carestia A, Etulain J, Pozner R, Fondevila C, Negrotto S, et al.
Thromb Res . 2013 Dec; 133(2):235-43. PMID: 24331207
Introduction: Platelets express Toll-like receptors (TLRs) that recognise molecular components of pathogens and, in nucleated cells, elicit immune responses through nuclear factor-kappaB (NF-κB) activation. We have shown that NF-κB mediates...
16.
Lapponi M, Carestia A, Landoni V, Rivadeneyra L, Etulain J, Negrotto S, et al.
J Pharmacol Exp Ther . 2013 Mar; 345(3):430-7. PMID: 23536315
The formation of neutrophil extracellular traps (NETs) is a newly described phenomenon that increases the bacteria-killing ability and the inflammatory response of neutrophils. Because NET generation occurs in an inflammatory...
17.
Romaniuk M, Croci D, Lapponi M, Tribulatti M, Negrotto S, Poirier F, et al.
FASEB J . 2012 Mar; 26(7):2788-98. PMID: 22456341
Understanding noncanonical mechanisms of platelet activation represents an important challenge for the identification of novel therapeutic targets in bleeding disorders, thrombosis, and cancer. We previously reported that galectin-1 (Gal-1), a...
18.
Lavelle D, Vaitkus K, Ling Y, Ruiz M, Mahfouz R, Ng K, et al.
Blood . 2011 Dec; 119(5):1240-7. PMID: 22160381
The deoxycytidine analog decitabine (DAC) can deplete DNA methyl-transferase 1 (DNMT1) and thereby modify cellular epigenetics, gene expression, and differentiation. However, a barrier to efficacious and accessible DNMT1-targeted therapy is...
19.
Etulain J, Negrotto S, Carestia A, Pozner R, Romaniuk M, DAtri L, et al.
Thromb Haemost . 2011 Dec; 107(1):99-110. PMID: 22159527
Acidosis is one of the hallmarks of tissue injury such as trauma, infection, inflammation, and tumour growth. Although platelets participate in the pathophysiology of all these processes, the impact of...
20.
Alcazar O, Achberger S, Aldrich W, Hu Z, Negrotto S, Saunthararajah Y, et al.
Int J Cancer . 2011 Jul; 131(1):18-29. PMID: 21796622
Apoptosis genes, such as TP53 and p16/CDKN2A, that mediate responses to cytotoxic chemotherapy, are frequently nonfunctional in melanoma. Differentiation may be an alternative to apoptosis for inducing melanoma cell cycle...