Human Plasmacytoid Dendritic Cells Elicited Different Responses After Infection with Pathogenic and Nonpathogenic Junin Virus Strains

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2015 May 1

PMID 25926646

Citations 9

Authors

Soledad Negrotto

Hebe A Mena

Agustin E Ure

Carolina Jaquenod De Giusti

Mariela Bollati-Fogolin

Elba M Vermeulen

Mirta Schattner

Ricardo M Gomez

Affiliations

Soon will be listed here.

Abstract

The arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection with the C#1 strain (attenuated) and even more susceptible to infection with the P (virulent) JUNV strain. However, hpDC elicited different responses in terms of viability, activation, maturation, and cytokine expression after infection with both JUNV strains.

Citing Articles

Nuclease Activity of the Junín Virus Nucleoprotein C-Terminal Domain.

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Regulation of Stress-Activated Kinases in Response to Tacaribe Virus Infection and Its Implications for Viral Replication.

Holzerland J, Feneant L, Groseth A Viruses. 2022; 14(9).

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The Virus-Host Interplay in Junín Mammarenavirus Infection.

Gallo G, Lopez N, Loureiro M Viruses. 2022; 14(6).

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Resident plasmacytoid dendritic cells patrol vessels in the naïve limbus and conjunctiva.

Jamali A, Harris D, Blanco T, Lopez M, Hamrah P Ocul Surf. 2020; 18(2):277-285.

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Lassa Virus, but Not Highly Pathogenic New World Arenaviruses, Restricts Immunostimulatory Double-Stranded RNA Accumulation during Infection.

Mateer E, Maruyama J, Card G, Paessler S, Huang C J Virol. 2020; 94(9).

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