Sofie Rutsaert
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Explore the profile of Sofie Rutsaert including associated specialties, affiliations and a list of published articles.
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25
Citations
447
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Recent Articles
1.
Delporte M, Lambrechts L, Blomme E, van Snippenberg W, Rutsaert S, Verschoore M, et al.
Clin Chem
. 2025 Jan;
71(1):203-214.
PMID: 39749517
Background: Persistent latent reservoirs of intact HIV-1 proviruses, capable of rebounding despite suppressive antiretroviral therapy (ART), hinder efforts towards an HIV-1 cure. Hence, assays specifically quantifying intact proviruses are crucial...
2.
Pardons M, Cole B, Lambrechts L, van Snippenberg W, Rutsaert S, Noppe Y, et al.
Nat Commun
. 2023 Dec;
14(1):8397.
PMID: 38110433
The development of latency reversing agents that potently reactivate HIV without inducing global T cell activation would benefit the field of HIV reservoir research and could pave the way to...
3.
Lambrechts L, Bonine N, Verstraeten R, Pardons M, Noppe Y, Rutsaert S, et al.
Nucleic Acids Res
. 2023 Oct;
51(20):e102.
PMID: 37819007
A deep understanding of the composition of the HIV-1 reservoir is necessary for the development of targeted therapies and the evaluation of curative efforts. However, current near full-length (NFL) HIV-1...
4.
Lambrechts L, Bonine N, Verstraeten R, Pardons M, Noppe Y, Rutsaert S, et al.
bioRxiv
. 2023 Jan;
PMID: 36711686
A deep understanding of the composition of the HIV-1 reservoir is necessary for the development of targeted therapies and the evaluation of curative efforts. However, current near full-length (NFL) HIV-1...
5.
Laeremans T, Dhaese S, Aernout J, Barbe K, Pannus P, Rutsaert S, et al.
AIDS
. 2022 Sep;
36(13):1761-1768.
PMID: 36172869
Objectives: Suppression of viral replication in patients on antiretroviral therapy (ART) is determined by plasma viral load (pVL) measurement. Whenever pVL reaches values below the limit of quantification, the qualitative...
6.
Malatinkova E, Thomas J, De Spiegelaere W, Rutsaert S, Geretti A, Pollakis G, et al.
Life (Basel)
. 2021 Dec;
11(12).
PMID: 34947941
Integrated HIV-1 DNA persists despite antiretroviral therapy and can fuel viral rebound following treatment interruption. Hence, methods to specifically measure the integrated HIV-1 DNA portion only are important to monitor...
7.
Zhang Z, Trypsteen W, Blaauw M, Chu X, Rutsaert S, Vandekerckhove L, et al.
BMC Med
. 2021 Nov;
19(1):282.
PMID: 34781942
Background: Combination antiretroviral treatment (cART) cannot eradicate HIV-1 from the body due to the establishment of persisting viral reservoirs which are not affected by therapy and reinitiate new rounds of...
8.
van Snippenberg W, Gleerup D, Rutsaert S, Vandekerckhove L, De Spiegelaere W, Trypsteen W
Methods
. 2021 May;
201:41-48.
PMID: 33992770
The development of an HIV-1 cure is hampered by the existence of a persistent (latent) reservoir that contains a small proportion of replication-competent intact proviruses which refuels viral replication upon...
9.
van de Wijer L, van der Heijden W, Ter Horst R, Jaeger M, Trypsteen W, Rutsaert S, et al.
Front Immunol
. 2021 May;
12:661990.
PMID: 33953724
Long-term changes in the immune system of successfully treated people living with HIV (PLHIV) remain incompletely understood. In this study, we assessed 108 white blood cell (WBC) populations in a...
10.
van der Heijden W, van de Wijer L, Keramati F, Trypsteen W, Rutsaert S, Ter Horst R, et al.
JCI Insight
. 2021 Feb;
6(7).
PMID: 33630761
Chronic inflammation and immune dysfunction play a key role in the development of non-AIDS-related comorbidities. The aim of our study was to characterize the functional phenotype of immune cells in...