Sofia N Moraes
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Explore the profile of Sofia N Moraes including associated specialties, affiliations and a list of published articles.
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12
Citations
184
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Recent Articles
1.
Moghadasi S, Moraes S, Harris R
J Mol Biol
. 2023 Oct;
435(23):168316.
PMID: 37858708
Deubiquitinases (DUBs) are proteolytic enzymes that catalyze the removal of ubiquitin from protein substrates. The critical role of DUBs in regulating protein ubiquitination makes them attractive drug targets in oncology,...
2.
Rieffer A, Chen Y, Salamango D, Moraes S, Harris R
CRISPR J
. 2023 Sep;
6(5):430-446.
PMID: 37672599
Precision genome editing has become a reality with the discovery of base editors. Cytosine base editor (CBE) technologies are improving rapidly but are mostly optimized for T dinucleotide targets. Here,...
3.
Fanunza E, Cheng A, Auerbach A, Stefanovska B, Moraes S, Lokensgard J, et al.
J Virol
. 2023 Aug;
97(8):e0078123.
PMID: 37565748
The APOBEC3 family of DNA cytosine deaminases comprises an important arm of the innate antiviral defense system. The gamma-herpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus and the alpha-herpesviruses herpes simplex...
4.
Moghadasi S, Heilmann E, Khalil A, Nnabuife C, Kearns F, Ye C, et al.
Sci Adv
. 2023 Mar;
9(13):eade8778.
PMID: 36989354
Vaccines and drugs have helped reduce disease severity and blunt the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, ongoing virus transmission, continuous evolution, and increasing selective pressures...
5.
Fanunza E, Cheng A, Auerbach A, Stefanovska B, Moraes S, Lokensgard J, et al.
bioRxiv
. 2023 Feb;
PMID: 36778493
Importance: Human cytomegalovirus (HCMV) infections can range from asymptomatic to severe, particularly in neonates and immunocompromised patients. HCMV has evolved strategies to overcome host-encoded antiviral defenses in order to achieve...
6.
Moraes S, Becker J, Moghadasi S, Shaban N, Auerbach A, Cheng A, et al.
Elife
. 2022 Dec;
11.
PMID: 36458685
Viruses have evolved diverse mechanisms to antagonize host immunity such as direct inhibition and relocalization of cellular APOBEC3B (A3B) by the ribonucleotide reductase (RNR) of Epstein-Barr virus. Here, we investigate...
7.
Auerbach A, Becker J, Moraes S, Moghadasi S, Duda J, Salamango D, et al.
mSphere
. 2022 Nov;
7(6):e0045122.
PMID: 36374108
APOBEC3B is an innate immune effector enzyme capable of introducing mutations in viral genomes through DNA cytosine-to-uracil editing. Recent studies have shown that gamma-herpesviruses, such as Epstein-Barr virus (EBV), have...
8.
Moghadasi S, Heilmann E, Khalil A, Nnabuife C, Kearns F, Ye C, et al.
bioRxiv
. 2022 Aug;
PMID: 35982678
Vaccines and drugs have helped reduce disease severity and blunt the spread of SARS-CoV-2. However, ongoing virus transmission, continuous evolution, and increasing selective pressures have the potential to yield viral...
9.
Shaban N, Yan R, Shi K, Moraes S, Cheng A, Carpenter M, et al.
Sci Adv
. 2022 Apr;
8(17):eabm2827.
PMID: 35476445
Viruses use a plethora of mechanisms to evade immune responses. A recent example is neutralization of the nuclear DNA cytosine deaminase APOBEC3B by the Epstein-Barr virus (EBV) ribonucleotide reductase subunit...
10.
Moghadasi S, Esler M, Otsuka Y, Becker J, Moraes S, Anderson C, et al.
mBio
. 2022 Apr;
13(3):e0078422.
PMID: 35471084
The main protease, M, of SARS-CoV-2 is required to cleave the viral polyprotein into precise functional units for virus replication and pathogenesis. Here, we report quantitative reporters for M function...