Adam Z Cheng
Overview
Explore the profile of Adam Z Cheng including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
258
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Recent Articles
1.
Fanunza E, Cheng A, Auerbach A, Stefanovska B, Moraes S, Lokensgard J, et al.
J Virol
. 2023 Aug;
97(8):e0078123.
PMID: 37565748
The APOBEC3 family of DNA cytosine deaminases comprises an important arm of the innate antiviral defense system. The gamma-herpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus and the alpha-herpesviruses herpes simplex...
2.
Ikeda T, Shimizu R, Nasser H, Carpenter M, Cheng A, Brown W, et al.
mBio
. 2023 Aug;
14(4):e0078223.
PMID: 37555667
HIV-1 must overcome multiple innate antiviral mechanisms to replicate in CD4 T lymphocytes and macrophages. Previous studies have demonstrated that the apolipoprotein B mRNA editing enzyme polypeptide-like 3 (APOBEC3, A3)...
3.
Ikeda T, Shimizu R, Nasser H, Carpenter M, Cheng A, Brown W, et al.
bioRxiv
. 2023 Apr;
PMID: 37034786
Importance: HIV-1 Vif neutralizes the HIV-1 restriction activity of A3 proteins. However, it is currently unclear whether Vif has additional essential cellular targets. To address this question, we disrupted to...
4.
Fanunza E, Cheng A, Auerbach A, Stefanovska B, Moraes S, Lokensgard J, et al.
bioRxiv
. 2023 Feb;
PMID: 36778493
Importance: Human cytomegalovirus (HCMV) infections can range from asymptomatic to severe, particularly in neonates and immunocompromised patients. HCMV has evolved strategies to overcome host-encoded antiviral defenses in order to achieve...
5.
Moraes S, Becker J, Moghadasi S, Shaban N, Auerbach A, Cheng A, et al.
Elife
. 2022 Dec;
11.
PMID: 36458685
Viruses have evolved diverse mechanisms to antagonize host immunity such as direct inhibition and relocalization of cellular APOBEC3B (A3B) by the ribonucleotide reductase (RNR) of Epstein-Barr virus. Here, we investigate...
6.
Yockteng-Melgar J, Shire K, Cheng A, Malik-Soni N, Harris R, Frappier L
J Virol
. 2022 Sep;
96(18):e0066022.
PMID: 36069545
Herpesvirus lytic infection causes cells to arrest at the G/S phase of the cell cycle by poorly defined mechanisms. In a prior study using fluorescent ubiquitination-based cell cycle indicator (FUCCI)...
7.
Shaban N, Yan R, Shi K, Moraes S, Cheng A, Carpenter M, et al.
Sci Adv
. 2022 Apr;
8(17):eabm2827.
PMID: 35476445
Viruses use a plethora of mechanisms to evade immune responses. A recent example is neutralization of the nuclear DNA cytosine deaminase APOBEC3B by the Epstein-Barr virus (EBV) ribonucleotide reductase subunit...
8.
Cheng A, Moraes S, Shaban N, Fanunza E, Bierle C, Southern P, et al.
Viruses
. 2021 Mar;
13(3).
PMID: 33671095
The APOBEC family of DNA cytosine deaminases provides a broad and overlapping defense against viral infections. Successful viral pathogens, by definition, have evolved strategies to escape restriction by the APOBEC...
9.
Cheng A, Moraes S, Attarian C, Yockteng-Melgar J, Jarvis M, Biolatti M, et al.
J Virol
. 2019 Sep;
93(23).
PMID: 31534038
An integral part of the antiviral innate immune response is the APOBEC3 family of single-stranded DNA cytosine deaminases, which inhibits virus replication through deamination-dependent and -independent activities. Viruses have evolved...
10.
Cheng A, Yockteng-Melgar J, Jarvis M, Malik-Soni N, Borozan I, Carpenter M, et al.
Nat Microbiol
. 2018 Nov;
4(1):78-88.
PMID: 30420783
The apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like (APOBEC) family of single-stranded DNA (ssDNA) cytosine deaminases provides innate immunity against virus and transposon replication. A well-studied mechanism is APOBEC3G...