Soazig Le Pennec
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Explore the profile of Soazig Le Pennec including associated specialties, affiliations and a list of published articles.
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10
Citations
120
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Recent Articles
1.
Keller L, Tardy C, Ligat L, Le Pennec S, Bery N, Koraichi F, et al.
Front Immunol
. 2022 Sep;
13:980539.
PMID: 36059552
Strategies based on intracellular expression of artificial binding domains present several advantages over manipulating nucleic acid expression or the use of small molecule inhibitors. Intracellularly-functional nanobodies can be considered as...
2.
Marchalot A, Ashi M, Lambert J, Carrion C, Lecardeur S, Srour N, et al.
Front Immunol
. 2020 Jun;
11:780.
PMID: 32477332
Class switch recombination (CSR) changes antibody isotype by replacing Cμ constant exons with different constant exons located downstream on the immunoglobulin heavy () locus. During CSR, transcription through specific switch...
3.
Dumont S, Le Pennec S, Donnart A, Teusan R, Steenman M, Chevalier C, et al.
Oncotarget
. 2018 Apr;
9(22):15883-15894.
PMID: 29662614
The PGC-1 (Peroxisome proliferator-activated receptor Gamma Coactivator-1) family of coactivators (PGC-1α, PGC-1β, and PRC) plays a central role in the transcriptional control of mitochondrial biogenesis and oxidative phosphorylation (OXPHOS) processes....
4.
Tarabichi M, Antoniou A, Le Pennec S, Gacquer D, de Saint Aubain N, Craciun L, et al.
J Clin Endocrinol Metab
. 2018 Jan;
103(3):1102-1111.
PMID: 29342254
Context: Although 60% of papillary thyroid carcinomas are BRAFV600E mutant (PTCV600E), the increased aggressiveness of these cancers is still debated. Objective: For PTCV600E we aimed to further characterize the extent...
5.
Le Pennec S, Konopka T, Gacquer D, Fimereli D, Tarabichi M, Tomas G, et al.
Endocr Relat Cancer
. 2015 Feb;
22(2):205-16.
PMID: 25691441
The contribution of intratumor heterogeneity to thyroid metastatic cancers is still unknown. The clonal relationships between the primary thyroid tumors and lymph nodes (LN) or distant metastases are also poorly...
6.
Mirebeau-Prunier D, Le Pennec S, Jacques C, Fontaine J, Gueguen N, Boutet-Bouzamondo N, et al.
PLoS One
. 2013 Mar;
8(3):e58683.
PMID: 23516535
Metabolic modifications of tumor cells are hallmarks of cancer. They exhibit an altered metabolism that allows them to sustain higher proliferation rates in hostile environment outside the cell. In thyroid...
7.
Le Pennec S, Mirebeau-Prunier D, Boutet-Bouzamondo N, Jacques C, Guillotin D, Lauret E, et al.
J Biol Chem
. 2011 Apr;
286(20):18229-39.
PMID: 21454643
Members of the peroxisome proliferator-activated receptor γ coactivator-1 family (i.e. PGC-1α, PGC-1β, and the PGC-1-related coactivator (PRC)) are key regulators of mitochondrial biogenesis and function. These regulators serve as mediators...
8.
Le Pennec S, Savagner F
Presse Med
. 2011 Mar;
40(7-8):683-9.
PMID: 21411270
MiRNAs are small noncoding RNA ensuring post-transcriptional regulation of gene expression. Their expression is tissue-specific and some miRNAs have diagnostic and/or prognostic interest for tumor classes. MiRNAs are involved in...
9.
Mirebeau-Prunier D, Le Pennec S, Jacques C, Gueguen N, Poirier J, Malthiery Y, et al.
FEBS J
. 2010 Jan;
277(3):713-25.
PMID: 20067526
Mitochondrial biogenesis, which depends on nuclear as well as mitochondrial genes, occurs in response to increased cellular ATP demand. The nuclear transcriptional factors, estrogen-related receptor alpha (ERRalpha) and nuclear respiratory...
10.
Raharijaona M, Le Pennec S, Poirier J, Mirebeau-Prunier D, Rouxel C, Jacques C, et al.
PLoS One
. 2009 Dec;
4(11):e7964.
PMID: 19956726
Background: The PGC-1 related coactivator (PRC), which shares structural and functional features with PGC-1alpha, is believed to regulate several metabolic pathways as well as mitochondrial biogenesis. Its involvement in the...