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Snehal Nirgude

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Recent Articles
1.
Nirgude S, Desai S, Ravindran F, Mhatre A, Mahadeva R, Sharma S, et al.
Int Immunopharmacol . 2025 Jan; 148:114127. PMID: 39870007
ROS (Reactive Oxygen Species) has a dual role in tumorigenesis. Some cancers have high ROS conditions, and others have low ROS. TNBC thrives on high ROS compared to other Breast...
2.
Nirgude S, Tichy E, Liu Z, Pradieu R, Byrne M, Gil De Gomez L, et al.
bioRxiv . 2024 Jul; PMID: 38948745
Beckwith-Wiedemann Syndrome (BWS) is an epigenetic overgrowth syndrome caused by methylation changes in the human 11p15 chromosomal locus. Patients with BWS exhibit tissue overgrowth, as well as an increased risk...
3.
Li Y, Xiao P, Boadu F, Goldkamp A, Nirgude S, Cheng J, et al.
medRxiv . 2024 Jan; PMID: 38168424
Beckwith-Wiedemann Syndrome (BWS, OMIM #130650) is a congenital epigenetic disorder in humans which affects approximately 1 in 10,340 children. The incidence is likely an underestimation as the condition is usually...
4.
Nirgude S, Naveh N, Kavari S, Traxler E, Kalish J
Br J Cancer . 2023 Dec; 130(4):638-650. PMID: 38142265
Background: Wilms tumor (WT) exhibits structural and epigenetic changes at chromosome 11p15, which also cause Beckwith-Wiedemann Syndrome (BWS). Children diagnosed with BWS have increased risk for WT. The aim of...
5.
Nirgude S, Desai S, Khanchandani V, Nagarajan V, Thumsi J, Choudhary B
PeerJ . 2023 Oct; 11:e16033. PMID: 37810779
Genetic heterogeneity influences the prognosis and therapy of breast cancer. The cause of disease progression varies and can be addressed individually. To identify the mutations and their impact on disease...
6.
Nirgude S, Shahana M V , Ravindran F, Kumar S, Sharma S, Mahadeva R, et al.
Molecules . 2023 Jul; 28(13). PMID: 37446888
Despite several treatment options for blood cancer, mortality remains high due to relapse and the disease's aggressive nature. Elevated levels of HSP90, a molecular chaperone essential for protein folding, are...
7.
Nirgude S, Desai S, Choudhary B
BMC Genomics . 2022 Dec; 23(1):807. PMID: 36474139
ST08 and ST09 are potent curcumin derivatives with antiproliferative, apoptotic, and migrastatic properties. Both ST08 and ST09 exhibit in vitro and in vivo anticancer properties. As reported earlier, these derivatives...
8.
Manjunath M, Nirgude S, Mhatre A, Vemuri S, Nataraj M, Thumsi J, et al.
Front Genet . 2022 Nov; 13:932060. PMID: 36386805
Breast cancer (BC) is one of the leading causes of cancer-associated death in women. Despite the progress in therapeutic regimen, resistance and recurrence of breast cancer have affected the overall...
9.
Nirgude S, Desai S, Mahadeva R, Ravindran F, Choudhary B
Front Oncol . 2022 May; 12:835027. PMID: 35615145
ST08 is a novel curcumin derivative that exhibited apoptotic and anti-migratory activity in MDA-MB-231, triple-negative breast cancer cells reported earlier. In this study, we further explored the anticancer properties of...
10.
Nirgude S, Desai S, Choudhary B
Cancer Rep (Hoboken) . 2022 Jan; 5(10):e1596. PMID: 34981672
Background: Curcumin is well known for its anticancer properties. Its cytotoxic activity has been documented in several cancer cell lines, including breast cancer. The pleiotropic activity of curcumin as an...