Smita Eknath Desale
Overview
Explore the profile of Smita Eknath Desale including associated specialties, affiliations and a list of published articles.
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15
Citations
109
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Recent Articles
1.
Chinnathambi S, Desale S
Adv Protein Chem Struct Biol
. 2024 Jul;
141:447-466.
PMID: 38960482
Alzheimer's disease is progressive neurodegenerative disease characterize by the presence of extracellular accumulation of amyloid-β plaques and intracellular deposits of neurofibrillary tangles of Tau. Apart from axonal depositions pathological aggregated...
2.
Desale S, Chidambaram H, Chinnathambi S
Methods Mol Biol
. 2024 Mar;
2754:471-481.
PMID: 38512683
Neuroinflammation is the brain condition that occurs due to the hyper-activation of brain's immune cells and microglia, over the stimulation of extracellular aggregated proteins such as amyloid plaques and by...
3.
Chidambaram H, Desale S, Chinnathambi S
Methods Mol Biol
. 2024 Mar;
2754:457-470.
PMID: 38512682
Microglia are the resident brain macrophage cells that are involved in constant surveillance of brain microenvironment. In Alzheimer's disease, microglia get over activated upon the accumulation of Tau and amyloid-β...
4.
Desale S, Chidambaram H, Chinnathambi S
Methods Mol Biol
. 2024 Mar;
2754:193-203.
PMID: 38512668
Alzheimer's disease (AD) is characterized by the abnormal accumulation of disordered protein, that is, extracellular senile plaques of amyloid-β (Aβ) and intracellular neurofibrillary tangles of Tau. Tau protein has gained...
5.
Chidambaram H, Desale S, Chinnathambi S
Methods Mol Biol
. 2024 Mar;
2754:33-54.
PMID: 38512659
Alzheimer's disease, a progressive neurological disorder, is characterized by the accumulation of neurofibrillary tangles and senile plaques by Tau and amyloid-β, respectively, in the brain microenvironment. The misfolded protein aggregates...
6.
Qureshi T, Desale S, Chidambaram H, Chinnathambi S
Methods Mol Biol
. 2024 Mar;
2761:257-266.
PMID: 38427242
Cytoskeletal dysregulation forms an important aspect of many neurodegenerative diseases such as Alzheimer's disease. Cytoskeletal functions require the dynamic activity of the cytoskeletal proteins-actin, tubulin, and the associated proteins. One...
7.
Desale S, Chidambaram H, Qureshi T, Chinnathambi S
Methods Mol Biol
. 2024 Mar;
2761:245-255.
PMID: 38427241
Alzheimer's disease (AD) is distinguished by extracellular accumulation of amyloid-beta plaques and intracellular neurofibrillary tangles of Tau. Pathogenic Tau species are also known to display "prion-like propagation," which explains their...
8.
Chidambaram H, Desale S, Qureshi T, Chinnathambi S
Methods Mol Biol
. 2024 Mar;
2761:231-243.
PMID: 38427240
Microglia are scavengers of the brain environment that clear dead cells, debris, and microbes. In Alzheimer's disease, microglia get activated to phagocytose damaged neurons, extracellular Amyoid-β, and Tau deposits. Several...
9.
Chinnathambi S, Das R, Desale S
Biochim Biophys Acta Mol Cell Res
. 2023 Apr;
1870(5):119477.
PMID: 37061007
Alzheimer's disease (AD) is a progressive neurodegenerative disease that is associated with protein misfolding, plaque accumulation, neuronal dysfunction, synaptic loss, and cognitive decline. The pathological cascade of AD includes the...
10.
Desale S, Chidambaram H, Chinnathambi S
Mol Biomed
. 2022 Jan;
2(1):17.
PMID: 35006431
Alzheimer's disease is a progressive neurodegenerative disease characterized by the presence of amyloid-β plaques in the extracellular environment and aggregates of Tau protein that forms neurofibrillary tangles (NFTs) in neuronal...