Sixian You
Overview
Explore the profile of Sixian You including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
522
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Recent Articles
1.
Han J, Liu K, Isaacson K, Monakhova K, Griffith L, You S
Nat Commun
. 2025 Jan;
16(1):745.
PMID: 39821085
Three-dimensional subcellular imaging is essential for biomedical research, but the diffraction limit of optical microscopy compromises axial resolution, hindering accurate three-dimensional structural analysis. This challenge is particularly pronounced in label-free...
2.
Liu K, Cao H, Shashaty K, Yu L, Spitz S, Pramotton F, et al.
Sci Adv
. 2024 Dec;
10(50):eadp2438.
PMID: 39661679
Label-free imaging through two-photon autofluorescence of NAD(P)H allows for nondestructive, high-resolution visualization of cellular activities in living systems. However, its application to thick tissues has been restricted by its limited...
3.
Yu L, You S
Sci Adv
. 2024 Jul;
10(27):eadn2846.
PMID: 38959310
High-precision light manipulation is crucial for delivering information through complex media. However, existing spatial light modulation devices face a fundamental speed-fidelity tradeoff. Digital micromirror devices have emerged as a promising...
4.
Guo R, Yang Q, Chang A, Hu G, Greene J, Gabel C, et al.
Light Sci Appl
. 2024 Jun;
13(1):144.
PMID: 38918363
Ultrafast 3D imaging is indispensable for visualizing complex and dynamic biological processes. Conventional scanning-based techniques necessitate an inherent trade-off between acquisition speed and space-bandwidth product (SBP). Emerging single-shot 3D wide-field...
5.
Qiu T, Cao H, Liu K, Yu L, Levy M, Lendaro E, et al.
Nat Commun
. 2024 Mar;
15(1):2031.
PMID: 38448415
Multimode fibers (MMFs) are gaining renewed interest for nonlinear effects due to their high-dimensional spatiotemporal nonlinear dynamics and scalability for high power. High-brightness MMF sources with effective control of the...
6.
Volpe G, Wahlby C, Tian L, Hecht M, Yakimovich A, Monakhova K, et al.
ArXiv
. 2023 Mar;
PMID: 36945686
Through digital imaging, microscopy has evolved from primarily being a means for visual observation of life at the micro- and nano-scale, to a quantitative tool with ever-increasing resolution and throughput....
7.
Park J, Kamerer R, Marjanovic M, Sorrells J, You S, Barkalifa R, et al.
Am J Cancer Res
. 2022 Jun;
12(5):2068-2083.
PMID: 35693090
Extracellular vesicles (EVs) have been studied for their potential applications in cancer screening, diagnosis, and treatment monitoring. Most studies have focused on the bulk content of EVs; however, it is...
8.
Baek A, Krawczynska N, Das Gupta A, Dvoretskiy S, You S, Park J, et al.
Endocrinology
. 2021 May;
162(7).
PMID: 33959755
Cholesterol has been implicated in the clinical progression of breast cancer, a disease that continues to be the most commonly diagnosed cancer in women. Previous work has identified the cholesterol...
9.
You S, Chaney E, Tu H, Sun Y, Sinha S, Boppart S
Cancer Res
. 2021 Mar;
81(9):2534-2544.
PMID: 33741692
Label-free nonlinear microscopy enables nonperturbative visualization of structural and metabolic contrast within living cells in their native tissue microenvironment. Here a computational pipeline was developed to provide a quantitative view...
10.
Boppart S, You S, Li L, Chen J, Tu H
APL Photonics
. 2021 Feb;
4(10).
PMID: 33585678
Without sophisticated data inversion algorithms, nonlinear optical microscopy can acquire images at subcellular resolution and relatively large depth, with plausible endogenous contrasts indicative of authentic biological and pathological states. Although...