Sivaraman Natarajan
Overview
Explore the profile of Sivaraman Natarajan including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
703
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Recent Articles
11.
Gonzalez-Pena V, Natarajan S, Xia Y, Klein D, Carter R, Pang Y, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(24).
PMID: 34099548
Improvements in whole genome amplification (WGA) would enable new types of basic and applied biomedical research, including studies of intratissue genetic diversity that require more accurate single-cell genotyping. Here, we...
12.
Autry R, Paugh S, Carter R, Shi L, Liu J, Ferguson D, et al.
Nat Cancer
. 2020 Sep;
1(3):329-344.
PMID: 32885175
Identification of genomic and epigenomic determinants of drug resistance provides important insights for improving cancer treatment. Using agnostic genome-wide interrogation of mRNA and miRNA expression, DNA methylation, SNPs, CNAs and...
13.
Goggin K, Gonzalez-Pena V, Inaba Y, Allison K, Hong D, Ahmed A, et al.
JAMA Oncol
. 2019 Dec;
6(4):552-556.
PMID: 31855231
Importance: Bloodstream infection (BSI) is a common, life-threatening complication of treatment for cancer. Predicting BSI before onset of clinical symptoms would enable preemptive therapy, but there is no reliable screening...
14.
Zhao Y, Carter R, Natarajan S, Varn F, Compton D, Gawad C, et al.
BMC Med Genomics
. 2019 Jun;
12(1):79.
PMID: 31151460
Background: Intra-tumor heterogeneity stems from genetic, epigenetic, functional, and environmental differences among tumor cells. A major source of genetic heterogeneity comes from DNA sequence differences and/or whole chromosome and focal...
15.
Ganuza M, Chabot A, Tang X, Bi W, Natarajan S, Carter R, et al.
Nat Commun
. 2018 Dec;
9(1):5405.
PMID: 30573729
The embryonic site of definitive hematopoietic stem cell (dHSC) origination has been debated for decades. Although an intra-embryonic origin is well supported, the yolk sac (YS) contribution to adult hematopoiesis...
16.
Dembla M, Kesharwani A, Natarajan S, Fecher-Trost C, Fairless R, Williams S, et al.
EMBO Mol Med
. 2018 Sep;
10(11).
PMID: 30266776
Optic neuritis is one of the first manifestations of multiple sclerosis. Its pathogenesis is incompletely understood, but considered to be initiated by an auto-immune response directed against myelin sheaths of...
17.
Cunha L, Yang M, Carter R, Guy C, Harris L, Crawford J, et al.
Cell
. 2018 Sep;
175(2):429-441.e16.
PMID: 30245008
Targeting autophagy in cancer cells and in the tumor microenvironment are current goals of cancer therapy. However, components of canonical autophagy play roles in other biological processes, adding complexity to...
18.
Carter R, Bihannic L, Rosencrance C, Hadley J, Tong Y, Phoenix T, et al.
Curr Biol
. 2018 Sep;
28(18):2910-2920.e2.
PMID: 30220501
The cerebellum develops from a restricted number of cell types that precisely organize to form the circuitry that controls sensory-motor coordination and some higher-order cognitive processes. To acquire an enhanced...
19.
Koh W, Gonzalez V, Natarajan S, Carter R, Brown P, Gawad C
PLoS One
. 2016 Oct;
11(10):e0164085.
PMID: 27736885
Circular RNAs comprise a poorly understood new class of noncoding RNA. In this study, we used a combination of targeted deletion, high-resolution splicing detection, and single-cell sequencing to deeply probe...
20.
Natarajan S, Li Y, Miller E, Shih D, Taylor M, Stearns T, et al.
Cancer Res
. 2013 Jul;
73(17):5381-90.
PMID: 23852537
While activation of the Notch pathway is observed in many human cancers, it is unknown whether elevated Notch1 expression is sufficient to initiate tumorigenesis in most tissues. To test the...