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Siva Thirugnanam

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Recent Articles
1.
Thirugnanam S, Wang C, Zheng C, Grasperge B, Datta P, Rappaport J, et al.
Int J Mol Sci . 2024 Aug; 25(16. PMID: 39201388
HIV-induced persistent immune activation is a key mediator of inflammatory comorbidities such as cardiovascular disease (CVD) and neurocognitive disorders. While a preponderance of data indicate that gut barrier disruption and...
2.
Thirugnanam S, Wang C, Zheng C, Grasperge B, Datta P, Rappaport J, et al.
bioRxiv . 2024 Jul; PMID: 38948748
HIV-induced persistent immune activation is a key mediator of inflammatory comorbidities such as cardiovascular disease (CVD) and neurocognitive disorders. While a preponderance of data indicate that gut barrier disruption and...
3.
Thirugnanam S, Rout N
Curr Issues Mol Biol . 2024 May; 46(5):4768-4786. PMID: 38785555
The emergence of combination antiretroviral therapy (cART) has greatly transformed the life expectancy of people living with HIV (PWH). Today, over 76% of the individuals with HIV have access to...
4.
Thirugnanam S, Walker E, Schiro F, Aye P, Rappaport J, Rout N
Viruses . 2023 Sep; 15(9). PMID: 37766350
Previous studies have indicated that the loss of CD161-expressing CD4 Th17 cells is linked to the progression of chronic HIV. These cells are significantly depleted in peripheral blood and gut...
5.
Fakharian F, Thirugnanam S, Welsh D, Kim W, Rappaport J, Bittinger K, et al.
Microorganisms . 2023 Jul; 11(7). PMID: 37513022
The gut microbiome plays a critical role in maintaining overall health and immune function. However, dysbiosis, an imbalance in microbiome composition, can have profound effects on various aspects of human...