Sinead M ODonovan
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Explore the profile of Sinead M ODonovan including associated specialties, affiliations and a list of published articles.
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46
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581
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Recent Articles
1.
Sahay S, Lundh A, Sirole R, McCullumsmith R, ODonovan S
Int J Mol Sci
. 2025 Mar;
26(5).
PMID: 40076453
Suicide is a major public health priority, and its molecular mechanisms appear to be related to imbalanced purine metabolism in the brain. This exploratory study investigates purinergic gene expression in...
2.
Zhang X, Valeri J, Eladawi M, Gisabella B, Garrett M, Vallender E, et al.
Schizophr Bull
. 2024 Nov;
PMID: 39526318
Background And Hypothesis: The amygdala, crucial for mood, anxiety, fear, and reward regulation, shows neuroanatomical and molecular divergence in psychiatric disorders like schizophrenia, bipolar disorder and major depression. This region...
3.
Hamoud A, Alganem K, Hanna S, Morran M, Henkel N, Imami A, et al.
Cell Commun Signal
. 2024 Oct;
22(1):501.
PMID: 39415254
Protein kinases are critical components of a myriad biological processes and strongly associated with various diseases. While kinase research has been a point of focus in biomedical research for several...
4.
Sahay S, Devine E, Vargas C, McCullumsmith R, ODonovan S
Cells
. 2024 Oct;
13(19.
PMID: 39404420
Schizophrenia is a neuropsychiatric illness characterized by altered neurotransmission, in which adenosine, a modulator of glutamate and dopamine, plays a critical role that is relatively unexplored in the human brain....
5.
Sahay S, Pulvender P, Rami Reddy M, McCullumsmith R, ODonovan S
Int J Mol Sci
. 2024 Aug;
25(15).
PMID: 39125835
The disruption of brain energy metabolism, leading to alterations in synaptic signaling, neural circuitry, and neuroplasticity, has been implicated in severe mental illnesses such as schizophrenia, bipolar disorder, and major...
6.
ODonovan S, Shan D, Wu X, Choi J, McCullumsmith R
Schizophr Bull
. 2024 Jun;
51(2):531-542.
PMID: 38825587
Background: Schizophrenia (SCZ) is a serious mental illness with complex pathology, including abnormalities in the glutamate system. Glutamate is rapidly removed from the synapse by excitatory amino acid transporters (EAATs)....
7.
Zhang X, Valeri J, Eladawi M, Gisabella B, Garrett M, Vallender E, et al.
medRxiv
. 2024 May;
PMID: 38699334
Background And Hypothesis: A growing number of studies implicate a key role for metabolic processes in psychiatric disorders. Recent studies suggest that ketogenic diet may be therapeutically effective for subgroups...
8.
Chelini G, Mirzapourdelavar H, Durning P, Baidoe-Ansah D, Sethi M, ODonovan S, et al.
Cell Rep
. 2024 Apr;
43(5):114112.
PMID: 38676925
Recent findings show that effective integration of novel information in the brain requires coordinated processes of homo- and heterosynaptic plasticity. In this work, we hypothesize that activity-dependent remodeling of the...
9.
Valeri J, Stiplosek C, ODonovan S, Sinclair D, Grant K, Bollavarapu R, et al.
Transl Psychiatry
. 2024 Feb;
14(1):115.
PMID: 38402197
Contextual triggers are significant factors contributing to relapse in substance use disorders (SUD). Emerging evidence points to a critical role of extracellular matrix (ECM) molecules as mediators of reward memories....
10.
Sahay S, Devine E, McCullumsmith R, ODonovan S
Cells
. 2024 Jan;
13(1).
PMID: 38201235
Schizophrenia is a devastating neuropsychiatric disorder associated with the dysregulation of glutamate and dopamine neurotransmitter systems. The adenosine system is an important neuroregulatory system in the brain that modulates glutamate...