Simone Thair
Overview
Explore the profile of Simone Thair including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
485
Followers
0
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Recent Articles
1.
Shojaei M, Chen U, Midic U, Thair S, Teoh S, McLean A, et al.
Eur J Clin Invest
. 2023 Jan;
53(5):e13957.
PMID: 36692131
Background: Indiscriminate use of antimicrobials and antimicrobial resistance is a public health threat. IMX-BVN-1, a 29-host mRNA classifier, provides two separate scores that predict likelihoods of bacterial and viral infections...
2.
Thair S, Mewes C, Hinz J, Bergmann I, Buttner B, Sehmisch S, et al.
Crit Care Med
. 2021 Apr;
49(8):e751-e760.
PMID: 33883455
Objectives: Early diagnosis of infections is pivotal in critically ill patients. Innovative gene expression-based approaches promise to deliver precise, fast, and clinically practicable diagnostic tools to bedside. This study aimed...
3.
Blauwkamp T, Thair S, Rosen M, Blair L, Lindner M, Vilfan I, et al.
Nat Microbiol
. 2019 Feb;
4(4):663-674.
PMID: 30742071
Thousands of pathogens are known to infect humans, but only a fraction are readily identifiable using current diagnostic methods. Microbial cell-free DNA sequencing offers the potential to non-invasively identify a...
4.
Andini N, Wang B, Athamanolap P, Hardick J, Masek B, Thair S, et al.
Sci Rep
. 2017 Feb;
7:42097.
PMID: 28165067
There is still an ongoing demand for a simple broad-spectrum molecular diagnostic assay for pathogenic bacteria. For this purpose, we developed a single-plex High Resolution Melt (HRM) assay that generates...
5.
Fjell C, Thair S, Hsu J, Walley K, Russell J, Boyd J
PLoS One
. 2013 Nov;
8(11):e79207.
PMID: 24244449
Introduction: Inflammatory response during sepsis is incompletely understood due to small sample sizes and variable timing of measurements following the onset of symptoms. The vasopressin in septic shock trial (VASST)...
6.
Thair S, Russell J
Curr Infect Dis Rep
. 2013 Aug;
15(5):364-71.
PMID: 23975688
NF-κB signaling plays a central role in the pathophysiology of severe sepsis and septic shock. Despite tremendous and missed efforts, novel therapeutics for severe sepsis and septic shock are still...
7.
Russell J, Fjell C, Hsu J, Lee T, Boyd J, Thair S, et al.
Am J Respir Crit Care Med
. 2013 Jun;
188(3):356-64.
PMID: 23796235
Rationale: Changes in plasma cytokine levels may predict mortality, and therapies (vasopressin versus norepinephrine) could change plasma cytokine levels in early septic shock. Objectives: Our hypotheses were that changes in...
8.
Russell J, Boyd J, Nakada T, Thair S, Walley K
Contrib Microbiol
. 2011 Jun;
17:48-85.
PMID: 21659747
In cancer, therapies are targeted at 6 important pathways. In sepsis, there is ongoing controversy regarding the number and relative roles of pathways that are activated or repressed and which...
9.
Hemida M, Ye X, Thair S, Yang D
Mol Diagn Ther
. 2010 Nov;
14(5):271-82.
PMID: 21053993
New therapeutic approaches are urgently needed for serious diseases, including cancer, cardiovascular diseases, viral infections, and others. A recent direction in drug development is the utilization of nucleic acid-based therapeutic...