Simone J C F M Moorlag
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Explore the profile of Simone J C F M Moorlag including associated specialties, affiliations and a list of published articles.
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63
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Recent Articles
1.
Setiabudiawan T, Apriani L, Verrall A, Utami F, Schneider M, Indrati A, et al.
Nat Commun
. 2025 Jan;
16(1):309.
PMID: 39747050
Some individuals, even when heavily exposed to an infectious tuberculosis patient, do not develop a specific T-cell response as measured by interferon-gamma release assay (IGRA). This could be explained by...
2.
Dulfer E, Fohse K, Taks E, Moorlag S, Koekenbier E, van de Maat J, et al.
J Infect
. 2024 Nov;
89(6):106344.
PMID: 39515666
Objectives: Previous research has suggested beneficial heterologous effects of the Bacillus Calmette-Guérin (BCG) vaccine on non-mycobacterial infections and other immune-mediated diseases. During the COVID-19 pandemic, randomized controlled trials BCG-PRIME (n ...
3.
Teufel L, Matzaraki V, Folkman L, Ter Horst R, Moorlag S, Mulders-Manders C, et al.
Clin Immunol
. 2024 Sep;
268:110368.
PMID: 39307482
Autoinflammatory diseases, while having a variety of underlying causes, are mediated by dysfunctional innate immune responses. Therefore, standard treatments target innate cytokines or block their receptors. Despite excellent responses in...
4.
Kilic G, Matzaraki V, Bulut O, Baydemir I, Ferreira A, Rabold K, et al.
Cell Immunol
. 2024 Aug;
403-404:104862.
PMID: 39159505
Trained immunity is a long-lasting change in the responsiveness of innate immune cells, leading to a stronger response upon an unrelated secondary challenge. Epigenetic, transcriptional, and metabolic reprogramming contribute to...
5.
Liu Z, Crisan T, Qi C, Gupta M, Liu X, Moorlag S, et al.
Res Sq
. 2024 Aug;
PMID: 39108482
Background: Urate concentration and the physiological regulation of urate homeostasis exhibit clear sex differences. DNA methylation has been shown to explain a substantial proportion of serum urate variance, mediate the...
6.
Roring R, Li W, Liu R, Bruno M, Zhang B, Debisarun P, et al.
iScience
. 2024 Mar;
27(4):109356.
PMID: 38510149
Familial Mediterranean fever (FMF) is a periodic fever syndrome caused by variation in . FMF is known for IL-1β dysregulation, but the innate immune landscape of this disease has not...
7.
Bulut O, Temba G, Koeken V, Moorlag S, de Bree L, Mourits V, et al.
Mech Ageing Dev
. 2024 Feb;
218:111916.
PMID: 38364983
In old age, impaired immunity causes high susceptibility to infections and cancer, higher morbidity and mortality, and poorer vaccination efficiency. Many factors, such as genetics, diet, and lifestyle, impact aging....
8.
Moorlag S, Folkman L, Ter Horst R, Krausgruber T, Barreca D, Schuster L, et al.
Immunity
. 2024 Jan;
57(1):171-187.e14.
PMID: 38198850
Immune responses are tightly regulated yet highly variable between individuals. To investigate human population variation of trained immunity, we immunized healthy individuals with Bacillus Calmette-Guérin (BCG). This live-attenuated vaccine induces...
9.
van Meijgaarden K, Li W, Moorlag S, Koeken V, Koenen H, Joosten L, et al.
Nat Commun
. 2024 Jan;
15(1):114.
PMID: 38167829
Bacillus Calmette-Guèrin - vaccination induces not only protection in infants and young children against severe forms of tuberculosis, but also against non-tuberculosis related all-cause mortality. To delineate different factors influencing...
10.
Peng C, Jiang X, Jaeger M, van Houten P, van Herwaarden A, Koeken V, et al.
EBioMedicine
. 2023 Dec;
99:104935.
PMID: 38134621
Background: Endogenous steroid hormones have significant effects on inflammatory and immune processes, but the immunological activities of steroidogenesis precursors remain largely unexplored. Methods: We conducted a systematic approach to examine...