Simone Ciofi-Baffoni
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Explore the profile of Simone Ciofi-Baffoni including associated specialties, affiliations and a list of published articles.
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83
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2197
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Recent Articles
1.
Grifagni D, Doni D, Susini B, Fonseca B, Louro R, Costantini P, et al.
Protein Sci
. 2024 Oct;
33(11):e5197.
PMID: 39467201
Episodic mitochondrial myopathy with or without optic atrophy and reversible leukoencephalopathy (MEOAL) is a rare, orphan autosomal recessive disorder caused by mutations in ferredoxin-2 (FDX2), which is a [2Fe-2S] cluster-binding...
2.
De Santis A, Grifagni D, Orsetti A, Lenci E, Rosato A, DOnofrio M, et al.
Biomolecules
. 2024 Oct;
14(10).
PMID: 39456193
The conservation of the main protease in viral genomes, combined with the absence of a homologous protease in humans, makes this enzyme family an ideal target for developing broad-spectrum antiviral...
3.
Querci L, Piccioli M, Ciofi-Baffoni S, Banci L
Biochim Biophys Acta Mol Cell Res
. 2024 Jun;
1871(7):119786.
PMID: 38901495
Over the last decade, structural aspects involving iron‑sulfur (Fe/S) protein biogenesis have played an increasingly important role in understanding the high mechanistic complexity of mitochondrial and cytosolic machineries maturing Fe/S...
4.
Grifagni D, Lenci E, De Santis A, Orsetti A, Barracchia C, Tedesco F, et al.
ACS Med Chem Lett
. 2024 Feb;
15(2):250-257.
PMID: 38352832
We have applied a proteolysis targeting chimera (PROTAC) technology to obtain a peptidomimetic molecule able to trigger the degradation of SARS-CoV-2 3-chymotrypsin-like protease (3CL). The PROTAC molecule was designed by...
5.
Da Vela S, Saudino G, Lucarelli F, Banci L, Svergun D, Ciofi-Baffoni S
J Mol Biol
. 2023 May;
435(15):168154.
PMID: 37211204
In humans, the biosynthesis and trafficking of mitochondrial [4Fe-4S] clusters is a highly coordinated process that requires a complex protein machinery. In a mitochondrial pathway among various proposed to biosynthesize...
6.
Bargagna B, Matteucci S, Ciofi-Baffoni S, Camponeschi F, Banci L
Protein Sci
. 2023 Mar;
32(5):e4625.
PMID: 36916754
[4Fe-4S] cluster assembly in human cytosol requires both a [2Fe-2S] cluster chaperone being able to donate two [2Fe-2S] clusters and an electron donor providing two electrons to reductively couple the...
7.
Abelein A, Ciofi-Baffoni S, Morman C, Kumar R, Giachetti A, Piccioli M, et al.
JACS Au
. 2022 Dec;
2(11):2571-2584.
PMID: 36465548
Metal ions, such as copper and zinc ions, have been shown to strongly modulate the self-assembly of the amyloid-β (Aβ) peptide into insoluble fibrils, and elevated concentrations of metal ions...
8.
Ji Y, Wei L, Da A, Stark H, Hagedoorn P, Ciofi-Baffoni S, et al.
Front Mol Biosci
. 2022 Nov;
9:1032220.
PMID: 36387278
No abstract available.
9.
Camponeschi F, Ciofi-Baffoni S, Calderone V, Banci L
Biomolecules
. 2022 Jul;
12(7).
PMID: 35883565
The importance of mitochondria in mammalian cells is widely known. Several biochemical reactions and pathways take place within mitochondria: among them, there are those involving the biogenesis of the iron-sulfur...
10.
Saudino G, Ciofi-Baffoni S, Banci L
J Am Chem Soc
. 2022 Mar;
144(13):5713-5717.
PMID: 35343688
Human lipoyl synthase (LIAS) is an enzyme containing two [4Fe-4S] clusters (named FeS and FeS) involved in the biosynthesis of the lipoyl cofactor. The mechanism by which a [4Fe-4S] cluster...