Simone Baltrusch
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Explore the profile of Simone Baltrusch including associated specialties, affiliations and a list of published articles.
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42
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560
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Recent Articles
1.
Langer S, Jagdhuhn D, Waterstradt R, Gromoll J, Muller M, Rees M, et al.
Metabolism
. 2025 Feb;
166:156150.
PMID: 39894388
Background: Regulation of glucose metabolism after a meal is the major task of hepatic glucokinase (GCK). Inhibition and nuclear retention of glucokinase during fasting is achieved by glucokinase regulatory protein...
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Langer S, Waterstradt R, Hillebrand G, Santer R, Baltrusch S
Diabetologia
. 2021 Sep;
64(12):2687-2700.
PMID: 34532767
Aims/hypothesis: The mammalian enzyme glucokinase (GK), expressed predominantly in liver and pancreas, plays an essential role in carbohydrate metabolism. Monogenic GK disorders emphasise the role of GK in determining the...
4.
Baltrusch S
Biomed Res Int
. 2021 Aug;
2021:9968228.
PMID: 34337067
Damage and regeneration naturally occur in the peripheral nervous system. The neurotropic B vitamins thiamine (B1), pyridoxine (B6), and cobalamin (B12) are key players, which maintain the neuronal viability in...
5.
Walckling M, Waterstradt R, Baltrusch S
Invest Ophthalmol Vis Sci
. 2020 Dec;
61(14):1.
PMID: 33259606
Purpose: To elucidate the collagen structure in the Descemet membrane (DM) of the human cornea and to characterize its rearrangement in patients with endothelial corneal dystrophies. Methods: Corneas from nine...
6.
Schultz J, Warkus J, Wolke C, Waterstradt R, Baltrusch S
Front Endocrinol (Lausanne)
. 2020 May;
11:232.
PMID: 32411091
Mitochondrial dynamics are important for glucose-stimulated insulin secretion in pancreatic beta cells. The mitochondrial elongation factor MiD51 has been proposed to act as an anchor that recruits Drp1 from the...
7.
Niemann J, Zehm C, Waterstradt R, Tiedge M, Baltrusch S
Cell Calcium
. 2019 Aug;
82:102055.
PMID: 31377553
Mitochondrial Ca flux is crucial for the regulation of cell metabolism. Ca entry to the mitochondrial matrix is mediated by VDAC1 and MCU with its regulatory molecules. We investigated hepatocytes...
8.
Langer S, Hofmeister-Brix A, Waterstradt R, Baltrusch S
Biochem Pharmacol
. 2019 Jun;
168:149-161.
PMID: 31254492
Glucokinase (GK), a monomeric glucose-phosphorylating enzyme characterised by high structural flexibility, acts as a glucose sensor in pancreatic beta cells and liver. Pharmaceutical efforts to control the enzyme are hampered...
9.
Reichart G, Mayer J, Zehm C, Kirschstein T, Tokay T, Lange F, et al.
Acta Physiol (Oxf)
. 2018 Oct;
225(4):e13214.
PMID: 30376218
Aim: Mitochondrial DNA (mtDNA) mutations can negatively influence lifespan and organ function. More than 250 pathogenic mtDNA mutations are known, often involving neurological symptoms. Major neurodegenerative diseases share key etiopathogenetic...
10.
Niemann J, Johne C, Schroder S, Koch F, Ibrahim S, Schultz J, et al.
Free Radic Biol Med
. 2016 Nov;
102:174-187.
PMID: 27890640
Mitochondrial dysfunction affects liver metabolism, but it remains unclear whether this interferes with normal liver aging. We investigated several mitochondrial pathways in hepatocytes and liver tissue from a conplastic mouse...