Simona Ursu
Overview
Explore the profile of Simona Ursu including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
721
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0
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Recent Articles
11.
Pesenacker A, Bending D, Ursu S, Wu Q, Nistala K, Wedderburn L
Blood
. 2013 Jan;
121(14):2647-58.
PMID: 23355538
Regulatory FoxP3+CD4+ T cells (Treg) are vital for maintaining the balance between tolerance, adequate immune response, and autoimmunity. Despite this immunoregulatory role, it has been shown that Treg may also...
12.
Omoyinmi E, Forabosco P, Hamaoui R, Bryant A, Hinks A, Ursu S, et al.
PLoS One
. 2012 Oct;
7(10):e47673.
PMID: 23094074
Background: The cytokine IL-10 and its family members have been implicated in autoimmune diseases and we have previously reported that genetic variants in IL-10 were associated with a rare group...
13.
Omoyinmi E, Hamaoui R, Pesenacker A, Nistala K, Moncrieffe H, Ursu S, et al.
Rheumatology (Oxford)
. 2012 Jul;
51(10):1881-6.
PMID: 22772320
Objective: The role of the adaptive immune system has not been explored in detail compared with the innate immune system in systemic JIA (sJIA) pathogenesis. The aim of this study...
14.
Holzinger D, Frosch M, Kastrup A, Prince F, Otten M, van Suijlekom-Smit L, et al.
Ann Rheum Dis
. 2012 Jan;
71(6):974-80.
PMID: 22267331
Background: Analysis of myeloid-related protein 8 and 14 complex (MRP8/14) serum concentrations is a potential new tool to support the diagnosis of systemic-onset juvenile idiopathic arthritis (SJIA) in the presence...
15.
Hinks A, Moncrieffe H, Martin P, Ursu S, Lal S, Kassoumeri L, et al.
Ann Rheum Dis
. 2011 Apr;
70(8):1395-400.
PMID: 21515602
Objectives: Methotrexate (MTX) is the mainstay treatment for juvenile idiopathic arthritis (JIA), however approximately 30% of children will fail to respond to the drug. Identification of genetic predictors of response...
16.
Moncrieffe H, Hinks A, Ursu S, Kassoumeri L, Etheridge A, Hubank M, et al.
Pharmacogenet Genomics
. 2010 Sep;
20(11):665-76.
PMID: 20827233
Objectives: Little is known about the mechanisms of efficacy of methotrexate (MTX) in childhood arthritis, or genetic influences upon response to MTX. The aims of this study were to use...
17.
Nistala K, Adams S, Cambrook H, Ursu S, Olivito B, de Jager W, et al.
Proc Natl Acad Sci U S A
. 2010 Aug;
107(33):14751-6.
PMID: 20679229
In several murine models of autoimmune arthritis, Th17 cells are the dominant initiators of inflammation. In human arthritis the majority of IL-17-secreting cells within the joint express a cytokine phenotype...
18.
Spadaro M, Ursu S, Lehmann-Horn F, Veneziano L, Liana V, Antonini G, et al.
Neurogenetics
. 2004 Oct;
5(3):177-85.
PMID: 15459825
Familial hemiplegic migraine (FHM) is an autosomal dominant subtype of migraine with hemiparesis during the aura. In over 50% of cases the causative gene is CACNA1A (FHM1), which in some...