Simona Dalin
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Explore the profile of Simona Dalin including associated specialties, affiliations and a list of published articles.
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13
Citations
285
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Recent Articles
1.
Chukwu W, Lee S, Crane A, Zhang S, Webster S, Dakhama O, et al.
Cell Rep Methods
. 2025 Mar;
:100991.
PMID: 40081367
Although several recent studies have characterized structural variants (SVs) in germline and cancer genomes independently, the genomic contexts of these SVs have not been comprehensively compared. We examined similarities and...
2.
Chukwu W, Lee S, Crane A, Zhang S, Webster S, Mittra I, et al.
bioRxiv
. 2023 Dec;
PMID: 38106141
Although several recent studies have characterized structural variants (SVs) in germline and cancer genomes, the features of SVs in these different contexts have not been directly compared. We examined similarities...
3.
Dalin S, Webster S, Sugawara N, Zhang S, Wu Q, Cui T, et al.
bioRxiv
. 2023 Oct;
PMID: 37873277
Double-strand break (DSB) repair is associated with a 1000-fold increase in mutations compared to normal replication of the same sequences. In budding yeast, repair of an HO endonuclease-induced DSB at...
4.
Dalin S, Grauman-Boss B, Lauffenburger D, Hemann M
Sci Rep
. 2022 Apr;
12(1):5453.
PMID: 35361803
Chemotherapy resistance is a major obstacle to curing cancer patients. Combination drug regimens have shown promise as a method to overcome resistance; however, to date only some cancers have been...
5.
Mueller H, Fowler C, Dalin S, Moiso E, Udomlumleart T, Garg S, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(34).
PMID: 34408017
Epigenetic regulators play key roles in cancer and are increasingly being targeted for treatment. However, for many, little is known about mechanisms of resistance to the inhibition of these regulators....
6.
Dalin S, Sullivan M, Lau A, Grauman-Boss B, Mueller H, Kreidl E, et al.
Cancer Res
. 2019 Sep;
79(22):5723-5733.
PMID: 31484670
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths in the United States. The deoxynucleoside analogue gemcitabine is among the most effective therapies to treat PDAC, however, nearly...
7.
Granit R, Masury H, Condiotti R, Fixler Y, Gabai Y, Glikman T, et al.
Cell Rep
. 2018 Sep;
24(12):3237-3250.
PMID: 30232005
Differentiation events contribute to phenotypic cellular heterogeneity within tumors and influence disease progression and response to therapy. Here, we dissect mechanisms controlling intratumoral heterogeneity within triple-negative basal-like breast cancers. Tumor...
8.
Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements
Pirhaji L, Milani P, Dalin S, Wassie B, Dunn D, Fenster R, et al.
Nat Commun
. 2017 Sep;
8(1):623.
PMID: 28931805
The immense and growing repositories of transcriptional data may contain critical insights for developing new therapies. Current approaches to mining these data largely rely on binary classifications of disease vs....
9.
Soltis A, Motola S, Vernia S, Ng C, Kennedy N, Dalin S, et al.
Sci Rep
. 2017 Mar;
7(1):174.
PMID: 28282965
Diet plays a crucial role in shaping human health and disease. Diets promoting obesity and insulin resistance can lead to severe metabolic diseases, while calorie-restricted (CR) diets can improve health...
10.
Sun D, Dalin S, Hemann M, Lauffenburger D, Zhao B
Sci Rep
. 2016 Nov;
6:36198.
PMID: 27819268
Recent drug discovery and development efforts have created a large arsenal of targeted and chemotherapeutic drugs for precision medicine. However, drug resistance remains a major challenge as minor pre-existing resistant...