Simon Sedej
Overview
Explore the profile of Simon Sedej including associated specialties, affiliations and a list of published articles.
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70
Citations
6084
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Recent Articles
1.
Abdellatif M, Vasques-Novoa F, Trummer-Herbst V, Durand S, Koser F, Islam M, et al.
Eur Heart J
. 2025 Feb;
PMID: 39995248
No abstract available.
2.
Liberale L, Tual-Chalot S, Sedej S, Ministrini S, Georgiopoulos G, Grunewald M, et al.
Nat Rev Cardiol
. 2025 Feb;
PMID: 39972009
Ageing of the cardiovascular system is associated with frailty and various life-threatening diseases. As global populations grow older, age-related conditions increasingly determine healthspan and lifespan. The circulatory system not only...
3.
Islam M, Rawnsley D, Ma X, Navid W, Zhao C, Guan X, et al.
J Clin Invest
. 2025 Feb;
PMID: 39932799
Protein aggregates are emerging therapeutic targets in rare monogenic causes of cardiomyopathy and amyloid heart disease, but their role in more prevalent heart failure syndromes remains mechanistically unexamined. We observed...
4.
Fuerlinger A, Stockner A, Sedej S, Abdellatif M
Cardiovasc Diabetol
. 2025 Jan;
24(1):21.
PMID: 39827109
The global increase in human life expectancy, coupled with an unprecedented rise in the prevalence of obesity, has led to a growing clinical and socioeconomic burden of heart failure with...
5.
Buttner P, Augstein A, Abdellatif M, Lourenco A, Leite-Moreira A, Falcao-Pires I, et al.
ESC Heart Fail
. 2024 Dec;
PMID: 39663741
Aims: ZSF1 obese rats harbouring two mutant leptin receptor alleles (Lepr and Lepr) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal...
6.
Islam M, Rawnsley D, Ma X, Navid W, Zhao C, Foroughi L, et al.
bioRxiv
. 2024 Sep;
PMID: 39282298
Protein aggregates are emerging therapeutic targets in rare monogenic causes of cardiomyopathy and amyloid heart disease, but their role in more prevalent heart failure syndromes remains mechanistically unexamined. We observed...
7.
Hofer S, Daskalaki I, Abdellatif M, Stelzl U, Sedej S, Tavernarakis N, et al.
Autophagy
. 2024 Aug;
20(12):2824-2826.
PMID: 39212197
Acute nutrient deprivation (fasting) causes an immediate increase in spermidine biosynthesis in yeast, flies, mice and humans, as corroborated in four independent clinical studies. This fasting-induced surge in spermidine constitutes...
8.
Hofer S, Daskalaki I, Bergmann M, Friscic J, Zimmermann A, Mueller M, et al.
Nat Cell Biol
. 2024 Aug;
26(9):1571-1584.
PMID: 39117797
Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human health. The natural polyamine spermidine has been similarly linked to autophagy enhancement, geroprotection and...
9.
Ozcan M, Abdellatif M, Javaheri A, Sedej S
Can J Cardiol
. 2024 Feb;
40(8):1445-1457.
PMID: 38354947
Population aging and the associated increase in cardiovascular disease rates pose serious threats to global public health. Different forms of fasting have become an increasingly attractive strategy to directly address...
10.
Akhmetshina A, Bianco V, Bradic I, Korbelius M, Pirchheim A, Kuentzel K, et al.
Mol Metab
. 2023 Dec;
79:101869.
PMID: 38160938
Objective: Lysosomal acid lipase (LAL) is the only enzyme known to hydrolyze cholesteryl esters (CE) and triacylglycerols in lysosomes at an acidic pH. Despite the importance of lysosomal hydrolysis in...