Simon Rose
Overview
Explore the profile of Simon Rose including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
1245
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Recent Articles
1.
Toubdji S, Thullier Q, Kilz L, Marchand V, Yuan Y, Sudol C, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(32):e2401981121.
PMID: 39078675
Dihydrouridine (D), a prevalent and evolutionarily conserved base in the transcriptome, primarily resides in tRNAs and, to a lesser extent, in mRNAs. Notably, this modification is found at position 2449...
2.
Nivette A, Zahnow R, Aguilar R, Ahven A, Amram S, Ariel B, et al.
Nat Hum Behav
. 2021 Jun;
5(7):868-877.
PMID: 34079096
The stay-at-home restrictions to control the spread of COVID-19 led to unparalleled sudden change in daily life, but it is unclear how they affected urban crime globally. We collected data...
3.
Rose S, Auxilien S, Havelund J, Kirpekar F, Huber H, Grosjean H, et al.
Nucleic Acids Res
. 2020 May;
48(12):6906-6918.
PMID: 32459340
The universal L-shaped tertiary structure of tRNAs is maintained with the help of nucleotide modifications within the D- and T-loops, and these modifications are most extensive within hyperthermophilic species. The...
4.
Sirand-Pugnet P, Bregeon D, Beven L, Goyenvalle C, Blanchard A, Rose S, et al.
Biomolecules
. 2020 Apr;
10(4).
PMID: 32290235
The C5-methylation of uracil to form 5-methyluracil (mU) is a ubiquitous base modification of nucleic acids. Four enzyme families have converged to catalyze this methylation using different chemical solutions. Here,...
5.
Guerin F, Rose S, Cattoir V, Douthwaite S
J Antimicrob Chemother
. 2019 Nov;
75(2):371-378.
PMID: 31670815
Objectives: To determine the mechanism of induction of erm(47) and its atypical expression in the Gram-positive opportunistic pathogen Helcococcus kunzii, where it confers resistance to a subset of clinically important...
6.
Beker M, Rose S, Lykkebo C, Douthwaite S
Front Microbiol
. 2018 Jul;
9:1329.
PMID: 29997583
Strains of the Pasteurellaceae bacteria and are major etiological agents of bovine respiratory disease (BRD). Treatment of BRD with antimicrobials is becoming more challenging due to the increasing occurrence of...
7.
Salamaszynska-Guz A, Rose S, Lykkebo C, Taciak B, Bacal P, Uspienski T, et al.
Front Cell Infect Microbiol
. 2018 Feb;
7:533.
PMID: 29404277
Numerous bacterial pathogens express an ortholog of the enzyme TlyA, which is an rRNA 2'--methyltransferase associated with resistance to cyclic peptide antibiotics such as capreomycin. Several other virulence traits have...
8.
Seistrup K, Rose S, Birkedal U, Nielsen H, Huber H, Douthwaite S
Nucleic Acids Res
. 2017 Feb;
45(4):2007-2015.
PMID: 28204608
In all free-living organisms a late-stage checkpoint in the biogenesis of the small ribosomal subunit involves rRNA modification by an RsmA/Dim1 methyltransferase. The hyperthermophilic archaeon Nanoarchaeum equitans, whose existence is...
9.
Borg Y, Grigonyte A, Boeing P, Wolfenden B, Smith P, Beaufoy W, et al.
PeerJ
. 2016 Jul;
4:e2031.
PMID: 27441104
Aim. The nascent field of bio-geoengineering stands to benefit from synthetic biologists' efforts to standardise, and in so doing democratise, biomolecular research methods. Roseobacter clade bacteria comprise 15-20% of oceanic...
10.
Lee S, Rose S, Metodiev M, Becker L, Vernaleken A, Klopstock T, et al.
Hum Mol Genet
. 2015 Oct;
24(25):7286-94.
PMID: 26464487
Mitochondrial dysfunction is a well-established cause of sensorineural deafness, but the pathophysiological events are poorly understood. Non-syndromic deafness and predisposition to aminoglycoside-induced deafness can be caused by specific mutations in...