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Simon Pimstone

Explore the profile of Simon Pimstone including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 59
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Recent Articles
1.
French J, Porter R, Perucca E, Brodie M, Rogawski M, Pimstone S, et al.
JAMA Neurol . 2023 Oct; 80(11):1145-1154. PMID: 37812429
Importance: Many patients with focal epilepsy experience seizures despite treatment with currently available antiseizure medications (ASMs) and may benefit from novel therapeutics. Objective: To evaluate the efficacy and safety of...
2.
Cutts A, Chowdhury S, Ratkay L, Eyers M, Young C, Namdari R, et al.
J Pharmacol Exp Ther . 2023 Mar; 386(1):4-14. PMID: 36958846
Divalent metal transporter 1 (DMT1) cotransports ferrous iron and protons and is the primary mechanism for uptake of nonheme iron by enterocytes. Inhibitors are potentially useful as therapeutic agents to...
3.
Trinder M, Vikulova D, Pimstone S, Mancini G, Brunham L
Atherosclerosis . 2021 Dec; 340:35-43. PMID: 34906840
Background And Aims: Familial combined hyperlipidemia (FCHL) is one of the most common inherited lipid phenotypes, characterized by elevated plasma concentrations of apolipoprotein B-100 and triglycerides. The genetic inheritance of...
4.
Cho R, Weng J, Lynch K, Ng P, Brown C, Hoens A, et al.
CJC Open . 2020 Mar; 1(3):107-114. PMID: 32159092
Background: Optimal design of clinical programs for patients with premature atherosclerotic cardiovascular disease (ASCVD) (men aged ≤ 50 years, women aged ≤ 55 years) requires an understanding of their priorities....
5.
Premoli I, Rossini P, Goldberg P, Posadas K, Green L, Yogo N, et al.
Ann Clin Transl Neurol . 2019 Oct; 6(11):2164-2174. PMID: 31568714
Objective: Transcranial magnetic stimulation (TMS) produces characteristic deflections in the EEG signal named TMS-evoked EEG potentials (TEPs), which can be used to assess drug effects on cortical excitability. TMS can...
6.
Brunham L, Lynch K, English A, Sutherland R, Weng J, Cho R, et al.
Clin Cardiol . 2018 Apr; 41(7):888-895. PMID: 29635745
Atherosclerotic cardiovascular disease (ASCVD) is highly heritable, particularly when it occurs at a young age. The screening of individuals with premature ASCVD, although often recommended, is not routinely performed. Strategies...
7.
Foucher C, Rattier S, Flavell D, Talmud P, Humphries S, Kastelein J, et al.
Pharmacogenetics . 2004 Dec; 14(12):823-9. PMID: 15608561
Objective: The association between polymorphisms in candidate genes related to lipoprotein metabolism and the reduction in plasma triglyceride (TG) in response to fenofibrate treatment was evaluated in subjects with type...
8.
Laurent C, Niehaus D, Bauche S, Levinson D, Soubigou S, Pimstone S, et al.
Am J Med Genet B Neuropsychiatr Genet . 2002 Dec; 116B(1):45-50. PMID: 12497613
The purpose of this study was to determine whether genetic linkage or association could be observed between schizophrenia (SZ) and the CAG repeat polymorphisms within the genes KCNN3 (known previously...