Simon P Preston
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Explore the profile of Simon P Preston including associated specialties, affiliations and a list of published articles.
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23
Citations
543
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Recent Articles
1.
Shuttleworth J, Lei C, Windley M, Hill A, Preston S, Mirams G
Philos Trans A Math Phys Eng Sci
. 2025 Mar;
383(2292):20240211.
PMID: 40078148
Mathematical models are increasingly being relied upon to provide quantitatively accurate predictions of cardiac electrophysiology. Many such models concern the behaviour of particular subcellular components (namely, ion channels) which, together,...
2.
Patten-Elliott F, Lei C, Preston S, Wilkinson R, Mirams G
Philos Trans A Math Phys Eng Sci
. 2025 Mar;
383(2292):20240227.
PMID: 40078143
The rapid delayed rectifier current carried by the human Ether-à-go-go-Related Gene (hERG) channel is susceptible to drug-induced reduction, which can lead to an increased risk of cardiac arrhythmia. Establishing the...
3.
Shuttleworth J, Lei C, Whittaker D, Windley M, Hill A, Preston S, et al.
Bull Math Biol
. 2023 Nov;
86(1):2.
PMID: 37999811
When using mathematical models to make quantitative predictions for clinical or industrial use, it is important that predictions come with a reliable estimate of their accuracy (uncertainty quantification). Because models...
4.
Arandjelovic P, Kim Y, Cooney J, Preston S, Doerflinger M, McMahon J, et al.
Cell Rep Med
. 2023 Aug;
4(9):101178.
PMID: 37652018
HIV-1 persists indefinitely in people living with HIV (PLWH) on antiretroviral therapy (ART). If ART is stopped, the virus rapidly rebounds from long-lived latently infected cells. Using a humanized mouse...
5.
Preston S, Allison C, Schaefer J, Clow W, M Bader S, Collard S, et al.
Cell Death Dis
. 2023 Feb;
14(2):123.
PMID: 36792599
Necroptosis is a lytic and inflammatory form of cell death that is highly constrained to mitigate detrimental collateral tissue damage and impaired immunity. These constraints make it difficult to define...
6.
Whittaker D, Herrera-Reyes A, Hendrix M, Owen M, Band L, Mirams G, et al.
J Theor Biol
. 2022 Nov;
558:111337.
PMID: 36351493
During the SARS-CoV-2 pandemic, epidemic models have been central to policy-making. Public health responses have been shaped by model-based projections and inferences, especially related to the impact of various non-pharmaceutical...
7.
Preston S, Stutz M, Allison C, Nachbur U, Gouil Q, Tran B, et al.
Gastroenterology
. 2022 Aug;
163(6):1643-1657.e14.
PMID: 36037995
Background & Aims: Necroptosis is a highly inflammatory mode of cell death that has been implicated in causing hepatic injury including steatohepatitis/ nonalcoholic steatohepatitis (NASH); however, the evidence supporting these...
8.
Band L, Nelissen H, Preston S, Rymen B, Prinsen E, AbdElgawad H, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(31):e2121288119.
PMID: 35878042
The hormone gibberellin (GA) controls plant growth and regulates growth responses to environmental stress. In monocotyledonous leaves, GA controls growth by regulating division-zone size. We used a systems approach to...
9.
M Bader S, Preston S, Saliba K, Lipszyc A, Grant Z, Mackiewicz L, et al.
Cell Death Differ
. 2022 Jul;
30(1):27-36.
PMID: 35871233
Caspase-8 transduces signals from death receptor ligands, such as tumor necrosis factor, to drive potent responses including inflammation, cell proliferation or cell death. This is a developmentally essential function because...
10.
Teh C, Preston S, Robbins A, Stutz M, Cooney J, Clark M, et al.
Sci Immunol
. 2022 Mar;
7(69):eabn8041.
PMID: 35333545
Targeting the potent immunosuppressive properties of FOXP3 regulatory T cells (T) has substantial therapeutic potential for treating autoimmune and inflammatory diseases. Yet, the molecular mechanisms controlling T homeostasis, particularly during...