Simon Musyoka Mwangi
Overview
Explore the profile of Simon Musyoka Mwangi including associated specialties, affiliations and a list of published articles.
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10
Citations
116
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Recent Articles
1.
Yang C, Mwangi S, Balasubramaniam A, Li G, Merlin-Zhang O, Liu Y, et al.
Gastro Hep Adv
. 2024 Feb;
3(1):38-47.
PMID: 38390283
Background And Aims: The overexpression of glial cell-derived neurotrophic factor (GDNF) in the liver and adipose tissues offers strong protection against high-fat diet (HFD)-induced obesity in mice. We hypothesize that...
2.
Balasubramaniam A, Li G, Ramanathan A, Mwangi S, Hart C, Arbiser J, et al.
Sci Rep
. 2022 Dec;
12(1):22076.
PMID: 36543902
Enteric neuron degeneration has been observed during aging, and in individuals with metabolic dysfunction including obesity and diabetes. Honokiol, a naturally occurring compound, is an activator of Sirtuin-3 (SIRT3) that...
3.
Mwangi S, Li G, Balasubramaniam A, Merlin D, Dawson P, Jang Y, et al.
Sci Rep
. 2022 Sep;
12(1):15838.
PMID: 36151131
Nonalcoholic fatty liver disease (NAFLD) is associated with increased oxidative stress that leads to hepatocyte and mitochondrial damage. In this study we investigated the mechanisms involved in the induction of...
4.
Chandramowlishwaran P, Vijay A, Abraham D, Li G, Mwangi S, Srinivasan S
Front Neurosci
. 2021 Jan;
14:614331.
PMID: 33414704
Neurodegeneration of the central and enteric nervous systems is a common feature of aging and aging-related diseases, and is accelerated in individuals with metabolic dysfunction including obesity and diabetes. The...
5.
Ye L, Li G, Goebel A, Raju A, Kong F, Lv Y, et al.
J Clin Invest
. 2020 Jun;
130(7):3621-3636.
PMID: 32484462
Enteric neuronal degeneration, as seen in inflammatory bowel disease, obesity, and diabetes, can lead to gastrointestinal dysmotility. Pyroptosis is a novel form of programmed cell death but little is known...
6.
Mwangi S, Li G, Ye L, Liu Y, Reichardt F, Yeligar S, et al.
Hepatology
. 2019 Feb;
69(6):2455-2470.
PMID: 30715741
Glial cell line-derived neurotrophic factor (GDNF) is a protein that is required for the development and survival of enteric, sympathetic, and catecholaminergic neurons. We previously reported that GDNF is protective...
7.
Taba Taba Vakili S, Kailar R, Rahman K, Nezami B, Mwangi S, Anania F, et al.
Liver Transpl
. 2015 Dec;
22(4):459-67.
PMID: 26714616
Moderate macrovesicular steatosis (>30%), which is present in almost 50% of livers considered for transplantation, increases the risk of primary graft dysfunction. Our previously published data showed that glial cell...
8.
Mwangi S, Peng S, Nezami B, Thorn N, Farris 3rd A, Jain S, et al.
Am J Physiol Gastrointest Liver Physiol
. 2015 Nov;
310(2):G103-16.
PMID: 26564715
Glial cell line-derived neurotrophic factor (GDNF) protects against high-fat diet (HFD)-induced hepatic steatosis in mice, however, the mechanisms involved are not known. In this study we investigated the effects of...
9.
Mwangi S, Nezami B, Obukwelu B, Anitha M, Marri S, Fu P, et al.
Am J Physiol Gastrointest Liver Physiol
. 2014 Jan;
306(6):G515-25.
PMID: 24458024
Obesity is a growing epidemic with limited effective treatments. The neurotrophic factor glial cell line-derived neurotrophic factor (GDNF) was recently shown to enhance β-cell mass and improve glucose control in...
10.
Mwangi S, Stabel T, Kehrli Jr M
Vet Immunol Immunopathol
. 2002 May;
86(3-4):251-4.
PMID: 12007891
Tumor necrosis factor-alpha (TNF-alpha) is a key mediator of inflammatory responses and gram-negative bacterial sepsis, but the role that it plays during Salmonella enterica species bacterial infections in swine has...