Simon M Cool
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Explore the profile of Simon M Cool including associated specialties, affiliations and a list of published articles.
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119
Citations
2749
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Recent Articles
1.
Smith R, Luo X, Lu X, Tan T, Le B, Zubkova O, et al.
Biomater Adv
. 2024 Nov;
155:213671.
PMID: 39492001
Bone morphogenetic protein 2 (BMP-2) is an osteoinductive protein and a potent inducers of bone formation, playing an essential role during bone fracture repair. Heparan sulfate (HS), a highly charged...
2.
Yan D, Chen D, Cool S, van Wijnen A, Mikecz K, Murphy G, et al.
Arthritis Res Ther
. 2024 Aug;
26(1):149.
PMID: 39113138
No abstract available.
3.
Daneshian Y, Lewallen E, Badreldin A, Dietz A, Stein G, Cool S, et al.
Crit Rev Eukaryot Gene Expr
. 2024 Jun;
34(6):37-60.
PMID: 38912962
Regenerative dental medicine continuously expands to improve treatments for prevalent clinical problems in dental and oral medicine. Stem cell based translational opportunities include regenerative therapies for tooth restoration, root canal...
4.
Shaffer K, Smith R, Daines A, Luo X, Lu X, Tan T, et al.
Carbohydr Polym
. 2024 Mar;
333:121979.
PMID: 38494232
Heparan sulfate (HS) is a glycosaminoglycan (GAG) found throughout nature and is involved in a wide range of functions including modulation of cell signalling via sequestration of growth factors. Current...
5.
Tan Kwan Zen N, Zeming K, Teo K, Loberas M, Lee J, Goh C, et al.
Lab Chip
. 2023 Sep;
23(19):4313-4323.
PMID: 37702123
The growing interest in regenerative medicine has opened new avenues for novel cell therapies using stem cells. Bone marrow aspirate (BMA) is an important source of stromal mesenchymal stem cells...
6.
Luo X, Lau C, Le B, Tan T, Too J, Smith R, et al.
Sci Rep
. 2023 Jul;
13(1):11774.
PMID: 37479738
It is challenging to regenerate periodontal tissues fully. We have previously reported a heparan sulfate variant with enhanced affinity for bone morphogenetic protein-2, termed HS3, that enhanced periodontal tissue regeneration...
7.
Srinivasan A, Sathiyanathan P, Yin L, Liu T, Lam A, Ravikumar M, et al.
Cytotherapy
. 2022 Mar;
24(5):456-472.
PMID: 35227601
Therapies using mesenchymal stromal cells (MSCs) to treat immune and inflammatory conditions are now at an exciting stage of development, with many MSC-based products progressing to phase II and III...
8.
Sargison L, Smith R, Carnachan S, Daines A, Brackovic A, Kidgell J, et al.
Carbohydr Polym
. 2022 Feb;
282:119081.
PMID: 35123736
Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions. As it is usually produced as a side-stream of pharmaceutical heparin manufacture, its...
9.
Zhang Y, Ling L, Ajay DO Ajayakumar A, Eio Y, van Wijnen A, Nurcombe V, et al.
Gene
. 2022 Jan;
818:146199.
PMID: 35093449
The multilineage differentiation potential of human mesenchymal stem cells (hMSCs) underpins their clinical utility for tissue regeneration. Control of such cell-fate decisions is tightly regulated by different growth factors/cytokines and...
10.
Lui H, Denbeigh J, Vaquette C, Tran H, Dietz A, Cool S, et al.
Gene
. 2021 Apr;
788:145662.
PMID: 33887373
Introduction: Culture conditions and differentiation cocktails may facilitate cell maturation and extracellular matrix (ECM) secretion and support the production of engineered fibroblastic tissues with applications in ligament regeneration. The objective...