Simon J Brookes
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Explore the profile of Simon J Brookes including associated specialties, affiliations and a list of published articles.
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27
Citations
439
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Recent Articles
1.
Wattchow D, Brookes S, Spencer N, Heitmann P, De Giorgio R, Costa M, et al.
ANZ J Surg
. 2023 Nov;
94(3):320-326.
PMID: 37974532
Motor function of the colon is essential for health. Our current understanding of the mechanisms that underlie colonic motility are based upon a range of experimental techniques, including molecular biology,...
2.
Wiklendt L, Mohd Rosli R, Kumar R, Paskaranandavadivel N, Bampton P, Maslen L, et al.
Am J Physiol Gastrointest Liver Physiol
. 2023 May;
325(1):G62-G79.
PMID: 37162180
Patients with irritable bowel syndrome (IBS) have recurrent lower abdominal pain, associated with altered bowel habit (diarrhea and/or constipation). As bowel habit is altered, abnormalities in colonic motility are likely...
3.
Xie Z, Feng J, Hibberd T, Chen B, Zhao Y, Zang K, et al.
Neuron
. 2022 Dec;
111(4):526-538.e4.
PMID: 36563677
Inflammatory and functional gastrointestinal disorders such as irritable bowel syndrome (IBS) and obstructive bowel disorder (OBD) underlie the most prevalent forms of visceral pain. Although visceral pain can be generally...
4.
Hibberd T, Yew W, Dodds K, Xie Z, Travis L, Brookes S, et al.
J Comp Neurol
. 2022 Aug;
530(18):3209-3225.
PMID: 36043843
Quantitative data of biological systems provide valuable baseline information for understanding pathology, experimental perturbations, and computational modeling. In mouse colon, calcitonin gene-related peptide (CGRP) is expressed by myenteric neurons with...
5.
Hibberd T, Costa M, Smolilo D, Keightley L, Brookes S, Dinning P, et al.
Am J Physiol Gastrointest Liver Physiol
. 2022 May;
323(2):G71-G87.
PMID: 35502864
Colonic motor complexes (CMCs) are a major neurogenic activity in guineapig distal colon. The identity of the enteric neurons that initiate this activity is not established. Specialized intrinsic primary afferent...
6.
Spencer N, Travis L, Wiklendt L, Costa M, Hibberd T, Brookes S, et al.
Commun Biol
. 2021 Aug;
4(1):955.
PMID: 34376798
How the Enteric Nervous System (ENS) coordinates propulsion of content along the gastrointestinal (GI)-tract has been a major unresolved issue. We reveal a mechanism that explains how ENS activity underlies...
7.
Heitmann P, Mohd Rosli R, Maslen L, Wiklendt L, Kumar R, Omari T, et al.
Neurogastroenterol Motil
. 2021 Jun;
34(1):e14178.
PMID: 34076936
Background: The colonic motor patterns associated with gas transit are poorly understood. This study describes the application of high-resolution impedance manometry (HRiM) in the human colon in vivo to characterize...
8.
Costa M, Keightley L, Hibberd T, Wiklendt L, Dinning P, Brookes S, et al.
Neurogastroenterol Motil
. 2021 Feb;
33(7):e14098.
PMID: 33586835
Background: In herbivores, the proximal and distal colonic regions feature distinct motor patterns underlying formation and propulsion of fecal pellets, respectively. Omnivores, such as mice and humans, lack a similar...
9.
Costa M, Keightley L, Hibberd T, Wiklendt L, Smolilo D, Dinning P, et al.
Neurogastroenterol Motil
. 2020 Nov;
33(5):e14047.
PMID: 33252184
Background: Colonic motor complexes (CMCs) have been widely recorded in the large intestine of vertebrates. We have investigated whether in the smooth muscle, a single unified pattern of electrical activity,...
10.
Spencer N, Hibberd T, Travis L, Wiklendt L, Costa M, Hu H, et al.
J Neurosci
. 2018 May;
38(24):5507-5522.
PMID: 29807910
The enteric nervous system (ENS) contains millions of neurons essential for organization of motor behavior of the intestine. It is well established that the large intestine requires ENS activity to...